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Your last paragraph is semiwrong. You can absolutely get sick with unadulterated cannabis but it's not dangerous just really unpleasant. I speak from experienc

Your last paragraph is semiwrong. You can absolutely get sick with unadulterated cannabis but it's not dangerous just really unpleasant. I speak from experience because I developed the cannabis hyperemesis syndrome. It happened when I switched to dry herb vaporization and the smoothness of the vapor made me unconsciously and insidiously increase the amount of cannabis I consumed per puff until I reach the ridiculous amount of .25g per puff. I know it was the syndrome and not some adulterated weed because applying capsaicin cream on my abdomen stopped the nausea.¹ When you are affected by that syndrome abstinence is the only permanent solution. So if someone like to indulge in cannabis, they should avoid to consume frequent concentrated doses. 1) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758720/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758720/

Mo3 4y ago
I stand corrected.. so we’re back at personal responsibility again. Last I read this was a very rare phenomenon happening mostly in chronic users of concentrates. I still fail to see how that is valid reasoning for anything else in this article.. Just read your comment again, but substitute cannabis with alcohol. You would be dead by now with these dosages, and if you go a step further the article would be correlating end stage liver disease with teens drinking a beer. I thought it was common sense that too much of anything is a bad idea. A rare phenomenon that mostly happens to the utter top quantile of chronic heavy users is absolutely invalid to use in that kind of generalization.
- bryans 4y ago
  Much like your original comment and despite having zero knowledge of the subject, you are arrogantly stringing together random words in an attempt to belittle people for being "stupid or naive." CHS is not rare, nor does it require extreme dosage. It affects approximately 7% of smokers. https://pubmed.ncbi.nlm.nih.gov/29327809/ https://pubmed.ncbi.nlm.nih.gov/29327809/
  - Mo3 4y ago
    > belittle people for being "stupid or naive." CHS is not rare, nor does it require extreme dosage. It affects approximately 7% of smokers. Allow me to quote directly from the article linked to by you, > Patients between the ages of 18-49 years who reported smoking marijuana at least 20 days per month. Among 2127 patients approached for participation, 155 met inclusion criteria as smoking 20 or more days per month. Among those surveyed, 32.9% (95% CI, 25.5-40.3%) met our criteria for having experienced CHS This puts the initial prevalence at around 2.3%, not 7%, but the dataset is also very small. Also, the dataset is likely biased because it consists of patients already presenting to the ER. There is no further mention as to why they presented to the emergency room either. > Patients were classified as experiencing a phenomenon consistent with CHS if they reported smoking marijuana at least 20 days per month and also rated 'hot showers' as five or more on the ten-point symptom relief method Likert scale for nausea and vomiting. These conditions are very broad and symptoms of CHS match closely the symptoms of regular overdose, and most of the relief methods are also directly applicable to regular overdoses. I would be extremely surprised if the actual prevalence is any higher than 0.5-1% of consumers, and in any case this has pretty much only proven my point now. I may have little knowledge on some rare edge-case condition, but at least I know how statistics work. For whatever it's worth, the prevalence of CHS seems to be lower than the prevalence of allergic reactions to alcohol.......
    - bryans 4y ago
      You're now making inflammatory claims about how you understand statistics better than NYU scientists and professors. Yet, all you've actually done is invent some numbers in your head and call them statistics, while also redefining bias. You even conveniently left out the rest of the researchers' quote which shows your premise is utter nonsense: "If this is extractable to the general population, approximately 2.75 million (2.13-3.38 million) Americans may suffer annually from a phenomenon similar to CHS." There are approximately 35,000,000 regular smokers. 2.75m / 35m is 7.8%. > Also, the dataset is likely biased because it consists of patients already presenting to the ER. That's not how bias works. In fact, you're introducing your own concocted bias, because you've limited the dataset to the ER visits and not the population. Your 2.3% number only represents the number of undiagnosed vomiting cases that could be attributed to CHS, which has no relevance to the number of smokers who experience vomiting. You don't have any understanding of statistics. > These conditions are very broad and symptoms of CHS match closely the symptoms of regular overdose, and most of the relief methods are also directly applicable to regular overdoses. You're now suggesting that these situations aren't actually marjiuana-related at all, but instead some other drug overdose that the ER staff totally missed. So, not only do you purport to understand statistics better than everyone else, but your medical expertise apparently surpasses that of ER doctors. Your trolling is outrageous.
- nick__m 4y ago
  I agree with most of your post. However, the article is about teens vaping concentrate that can contains as much as 90% THC. The title on HN is misleading, the article is not about teens smoking a few joints per week. To reuse your alcohol analogy, the article would be about teens drinking undiluted alcohol (94%) and the title on HN would be "Teens drinking beer are frequently found dead"
  - Mo3 4y ago
    You're right, that one is way better.

Mo3 4y ago

I stand corrected.. so we’re back at personal responsibility again. Last I read this was a very rare phenomenon happening mostly in chronic users of concentrates. I still fail to see how that is valid reasoning for anything else in this article.. Just read your comment again, but substitute cannabis with alcohol. You would be dead by now with these dosages, and if you go a step further the article would be correlating end stage liver disease with teens drinking a beer. I thought it was common sense that too much of anything is a bad idea. A rare phenomenon that mostly happens to the utter top quantile of chronic heavy users is absolutely invalid to use in that kind of generalization.

bryans 4y ago
Much like your original comment and despite having zero knowledge of the subject, you are arrogantly stringing together random words in an attempt to belittle people for being "stupid or naive." CHS is not rare, nor does it require extreme dosage. It affects approximately 7% of smokers. https://pubmed.ncbi.nlm.nih.gov/29327809/ https://pubmed.ncbi.nlm.nih.gov/29327809/
- Mo3 4y ago
  > belittle people for being "stupid or naive." CHS is not rare, nor does it require extreme dosage. It affects approximately 7% of smokers. Allow me to quote directly from the article linked to by you, > Patients between the ages of 18-49 years who reported smoking marijuana at least 20 days per month. Among 2127 patients approached for participation, 155 met inclusion criteria as smoking 20 or more days per month. Among those surveyed, 32.9% (95% CI, 25.5-40.3%) met our criteria for having experienced CHS This puts the initial prevalence at around 2.3%, not 7%, but the dataset is also very small. Also, the dataset is likely biased because it consists of patients already presenting to the ER. There is no further mention as to why they presented to the emergency room either. > Patients were classified as experiencing a phenomenon consistent with CHS if they reported smoking marijuana at least 20 days per month and also rated 'hot showers' as five or more on the ten-point symptom relief method Likert scale for nausea and vomiting. These conditions are very broad and symptoms of CHS match closely the symptoms of regular overdose, and most of the relief methods are also directly applicable to regular overdoses. I would be extremely surprised if the actual prevalence is any higher than 0.5-1% of consumers, and in any case this has pretty much only proven my point now. I may have little knowledge on some rare edge-case condition, but at least I know how statistics work. For whatever it's worth, the prevalence of CHS seems to be lower than the prevalence of allergic reactions to alcohol.......
  - bryans 4y ago
    You're now making inflammatory claims about how you understand statistics better than NYU scientists and professors. Yet, all you've actually done is invent some numbers in your head and call them statistics, while also redefining bias. You even conveniently left out the rest of the researchers' quote which shows your premise is utter nonsense: "If this is extractable to the general population, approximately 2.75 million (2.13-3.38 million) Americans may suffer annually from a phenomenon similar to CHS." There are approximately 35,000,000 regular smokers. 2.75m / 35m is 7.8%. > Also, the dataset is likely biased because it consists of patients already presenting to the ER. That's not how bias works. In fact, you're introducing your own concocted bias, because you've limited the dataset to the ER visits and not the population. Your 2.3% number only represents the number of undiagnosed vomiting cases that could be attributed to CHS, which has no relevance to the number of smokers who experience vomiting. You don't have any understanding of statistics. > These conditions are very broad and symptoms of CHS match closely the symptoms of regular overdose, and most of the relief methods are also directly applicable to regular overdoses. You're now suggesting that these situations aren't actually marjiuana-related at all, but instead some other drug overdose that the ER staff totally missed. So, not only do you purport to understand statistics better than everyone else, but your medical expertise apparently surpasses that of ER doctors. Your trolling is outrageous.
nick__m 4y ago
I agree with most of your post. However, the article is about teens vaping concentrate that can contains as much as 90% THC. The title on HN is misleading, the article is not about teens smoking a few joints per week. To reuse your alcohol analogy, the article would be about teens drinking undiluted alcohol (94%) and the title on HN would be "Teens drinking beer are frequently found dead"
- Mo3 4y ago
  You're right, that one is way better.