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If the virus escapes antibody response (Original Antigenic Sin?), how is the vaccine still preventing severe infection and hospitalisation? It also says most p
by headsoup 4y ago
If the virus escapes antibody response (Original Antigenic Sin?), how is the vaccine still preventing severe infection and hospitalisation?
It also says most prior infections were also vaccinated. It would be interesting to see if the unvaccinated with previous infection are also as susceptible. If not, this would be a good candidate for OAS, which was raised quite a bit by the 'conspiracy nuts' early on in the vaccine rollout.
- WalterGR 4y agoWhat was the evidence at that time?
- headsoup 4y agoA vaccine created to target a specific protein and years of virology experience in predicting where that would lead. I'm not one of those virologists, but it's not an unreasonable issue to foresee, with OAS a known effect.
- sp332 4y ago"We observed 3-fold reductions of neutralizing antibody titers induced by vaccination and infection against BA4 and BA5 compared with BA1 and BA2, which are already substantially lower than the original COVID-19 variants" The immune response is lower but not zero.
- verdverm 4y agoThe new virus is also less deadly than the earlier variants, generally speaking