4 ms·

What does "vaccine-derived" mean? What is the relation between the detected virus and the virus used in vaccines?

Fomite 4y ago
In countries that struggle with polio vaccination, we often use a "live attenuated" vaccine - that is, you are getting an infection with live virus, but one that has been engineered to cause little to no disease. The advantages of this are that it's very easy to administer (this is the classic "vaccine dropper onto a kid's tongue" image), and because you shed the attenuated virus, you can help boost the immunity of those who aren't directly vaccinated. The downside is for the polio vaccine that it occasionally reverts back to a type that causes active disease. This is rare, but definitely happens, and this is one of those cases.
M2Ys4U 4y ago
There are two types of vaccine in use: An inactivated virus and live, attenuated virus. Very occasionally the attenuated virus version can cause onward polio infections, i.e. the vaccinated individual can pass the virus on to others.
- arghwhat 4y ago
  *in use for polio. Many other types of vaccine exist, and modern vaccines tend to be neither inactivated nor attenuated virus.
- FartyMcFarter 4y ago
  Unfortunately some people will assume that all vaccines are the same type as this one, and they'll use this as an argument for why vaccines are bad :(
  - plsbenice34 4y ago
    Hopefully some people will realise that all vaccines do entail risks, too
    - wonderwonder 4y ago
      I don't think most people see zero risk with vaccines but they are smart enough to look at the real (not anti vax) statistics and realize that the risks are far outweighed by the benefits to both the individual and the community. Polio, a virus that used to cause 15k cases of paralysis a year in the us and 2k deaths is virtually eliminated due to the vaccine. The risk of course is when the vaccines are defective such as with The Cutter Incident in the 1955. This was probably the root of the modern anti-vax movement. There is also always the chance of a negative reaction to the vaccine as well. With that said, the modern anti-vax movement is for the most part a conspiracy driven group of people that look only for proof that support what they want to see and they are quite happy to not look to deeply into the source of that proof or quite often to even read further than what the local mom posted on facebook.
      - benjaminwootton 4y ago
        Agree. In my entire life I don’t think I’ve heard anyone question if the usual childhood vaccinations are worth taking. They know that risk is greater than reward. There was however a lot of skepticism and debate about the Covid vaccine because risk/reward is much more ambiguous.
        wonderwonder 4y ago
        Covid was interesting from an antivax perspective. It started off as pretty dangerous and scary. Lots of people dying very fast. Then it started to get less dangerous quickly as it mutated. In the meantime the vaccine was rolled out and people questioned why should I take a novel vaccine for something that for the most part appears no worse than the flu. Which I completely get. Then they started associating every single negative thing that happened to being vaccinated and things went off the deep end. With that said, my brother is not vaccinated against covid and I totally get it.
        Fomite 4y ago
        The COVID-19 vaccine has fully spilled over into outright skepticism about childhood vaccines: https://www.tennessean.com/story/news/health/2021/07/13/tennessee-halts-all-vaccine-outreach-minors-not-just-covid-19/7928701002/ https://www.tennessean.com/story/news/health/2021/07/13/tenn...
  - avs733 4y ago

In countries that struggle with polio vaccination, we often use a "live attenuated" vaccine - that is, you are getting an infection with live virus, but one that has been engineered to cause little to no disease. The advantages of this are that it's very easy to administer (this is the classic "vaccine dropper onto a kid's tongue" image), and because you shed the attenuated virus, you can help boost the immunity of those who aren't directly vaccinated. The downside is for the polio vaccine that it occasionally reverts back to a type that causes active disease. This is rare, but definitely happens, and this is one of those cases.

M2Ys4U 4y ago

There are two types of vaccine in use: An inactivated virus and live, attenuated virus. Very occasionally the attenuated virus version can cause onward polio infections, i.e. the vaccinated individual can pass the virus on to others.

arghwhat 4y ago
*in use for polio. Many other types of vaccine exist, and modern vaccines tend to be neither inactivated nor attenuated virus.
FartyMcFarter 4y ago
Unfortunately some people will assume that all vaccines are the same type as this one, and they'll use this as an argument for why vaccines are bad :(
- plsbenice34 4y ago
  Hopefully some people will realise that all vaccines do entail risks, too
  - wonderwonder 4y ago
    I don't think most people see zero risk with vaccines but they are smart enough to look at the real (not anti vax) statistics and realize that the risks are far outweighed by the benefits to both the individual and the community. Polio, a virus that used to cause 15k cases of paralysis a year in the us and 2k deaths is virtually eliminated due to the vaccine. The risk of course is when the vaccines are defective such as with The Cutter Incident in the 1955. This was probably the root of the modern anti-vax movement. There is also always the chance of a negative reaction to the vaccine as well. With that said, the modern anti-vax movement is for the most part a conspiracy driven group of people that look only for proof that support what they want to see and they are quite happy to not look to deeply into the source of that proof or quite often to even read further than what the local mom posted on facebook.
    - benjaminwootton 4y ago
      Agree. In my entire life I don’t think I’ve heard anyone question if the usual childhood vaccinations are worth taking. They know that risk is greater than reward. There was however a lot of skepticism and debate about the Covid vaccine because risk/reward is much more ambiguous.
      - wonderwonder 4y ago
        Covid was interesting from an antivax perspective. It started off as pretty dangerous and scary. Lots of people dying very fast. Then it started to get less dangerous quickly as it mutated. In the meantime the vaccine was rolled out and people questioned why should I take a novel vaccine for something that for the most part appears no worse than the flu. Which I completely get. Then they started associating every single negative thing that happened to being vaccinated and things went off the deep end. With that said, my brother is not vaccinated against covid and I totally get it.
      - Fomite 4y ago
        The COVID-19 vaccine has fully spilled over into outright skepticism about childhood vaccines: https://www.tennessean.com/story/news/health/2021/07/13/tennessee-halts-all-vaccine-outreach-minors-not-just-covid-19/7928701002/ https://www.tennessean.com/story/news/health/2021/07/13/tenn...
- avs733 4y ago