4 ms·

But it might be that they get a buzz as an evolutionary strategy, similar to why humans find sugar so appealing (it signifies caloric density). So the cats cert

But it might be that they get a buzz as an evolutionary strategy, similar to why humans find sugar so appealing (it signifies caloric density). So the cats certainly get a high but maybe they get the high because of the insect repellent action of iridoids (per the article; I don't have any special knowledge of this).

BudaDude 4y ago
That could be true. But it could be like weed where Human brains have receptors for Cannbanoids but they don't do much without the help of weed.
- derrasterpunkt 4y ago
  There are lots of cannabinoid receptors in the body and the body produces its own cannabinoids (e.g. Anandamide). There is no need for weed – when it comes to those receptors.
  - autoexec 4y ago
    This makes me wonder about the people who seem immune to the effects of cannabis. If the problem is their receptors would that impair their ability to take advantage of Anandamide and the body's other cannabinoids as well and if so, what are the impacts?
    - aaaaaaaaaaab 4y ago
      No. Their mutated receptors can reject THC while still accepting their own endocannabinoids.
      - 0des 4y ago
        Every time I have encountered one of these people, they try a single dab and suddenly it's myth-busted.
        autoexec 4y ago
        It seems pretty common for people to not have or notice any effects the first few times they try it, so some people may think they're one of the immune until they aren't, but I've met a few who do seem unaffected after many attempts. Some say they don't get that natural "runners high" either. It's all just subjective and anecdotal though. I haven't personally seen research on the subject yet.
        hallway_monitor 4y ago
        I've gotten plenty high but never this elusive runners high people talk about. I guess it must be why some people like to run more than half a mile and I'm missing out!
        ksaj 4y ago
        I've only experienced Runner's High one time that I am aware of. I was never a good runner. But in grade 7 and 8 we used to run a regular route for gym class. I always had to walk parts of it. But in grade 8, we had "The Great Race" and for whatever reason, I guess since it wasn't just my usual gym classmates, I got all competitive and managed to run the whole thing. I still lagged way too far to win, but I made it without stopping. There was a point, a ways after the first point I would normally give up and walk a bit, that I suddenly felt "This is easy" and everything just flowed. So I just kept going and finished the race. When it was over, it was a chore trying not to vomit. That was a definite breakthrough stamina moment.
        ksaj 4y ago
        This is correct. I've heard about this a fair amount afterward, but when I first tried it in grade 7, I got absolutely nothing from it the first time. I smoked tobacco then, so I was plenty experienced with inhaling etc. The lack of effect made me feel a bit cocky, so the next time I went in all bravado. I got super stoned and could barely stand or walk while I was adjusting to it. I was quite impressed and humbled immediately. Nowadays I get runners high running for my stash. Kidding. The rest is true though.
- kuhewa 4y ago
  We don't yet understand the endocannabinoid system in great detail, but all signs point to it having critical roles in a number of physiological processes including memory, mood, fertility, immune response, appetite etc. Cannabinoid receptors 'don't do much' without the help of of some 19% THC sativa in the same way the dopaminergic system doesn't do much without the help of methamphetamine. However, that 'not much' is actually necessary for us to function.

BudaDude 4y ago

That could be true. But it could be like weed where Human brains have receptors for Cannbanoids but they don't do much without the help of weed.

derrasterpunkt 4y ago
There are lots of cannabinoid receptors in the body and the body produces its own cannabinoids (e.g. Anandamide). There is no need for weed – when it comes to those receptors.
- autoexec 4y ago
  This makes me wonder about the people who seem immune to the effects of cannabis. If the problem is their receptors would that impair their ability to take advantage of Anandamide and the body's other cannabinoids as well and if so, what are the impacts?
  - aaaaaaaaaaab 4y ago
    No. Their mutated receptors can reject THC while still accepting their own endocannabinoids.
    - 0des 4y ago
      Every time I have encountered one of these people, they try a single dab and suddenly it's myth-busted.
      - autoexec 4y ago
        It seems pretty common for people to not have or notice any effects the first few times they try it, so some people may think they're one of the immune until they aren't, but I've met a few who do seem unaffected after many attempts. Some say they don't get that natural "runners high" either. It's all just subjective and anecdotal though. I haven't personally seen research on the subject yet.
        hallway_monitor 4y ago
        I've gotten plenty high but never this elusive runners high people talk about. I guess it must be why some people like to run more than half a mile and I'm missing out!
        ksaj 4y ago
        I've only experienced Runner's High one time that I am aware of. I was never a good runner. But in grade 7 and 8 we used to run a regular route for gym class. I always had to walk parts of it. But in grade 8, we had "The Great Race" and for whatever reason, I guess since it wasn't just my usual gym classmates, I got all competitive and managed to run the whole thing. I still lagged way too far to win, but I made it without stopping. There was a point, a ways after the first point I would normally give up and walk a bit, that I suddenly felt "This is easy" and everything just flowed. So I just kept going and finished the race. When it was over, it was a chore trying not to vomit. That was a definite breakthrough stamina moment.
        ksaj 4y ago
        This is correct. I've heard about this a fair amount afterward, but when I first tried it in grade 7, I got absolutely nothing from it the first time. I smoked tobacco then, so I was plenty experienced with inhaling etc. The lack of effect made me feel a bit cocky, so the next time I went in all bravado. I got super stoned and could barely stand or walk while I was adjusting to it. I was quite impressed and humbled immediately. Nowadays I get runners high running for my stash. Kidding. The rest is true though.
kuhewa 4y ago
We don't yet understand the endocannabinoid system in great detail, but all signs point to it having critical roles in a number of physiological processes including memory, mood, fertility, immune response, appetite etc. Cannabinoid receptors 'don't do much' without the help of of some 19% THC sativa in the same way the dopaminergic system doesn't do much without the help of methamphetamine. However, that 'not much' is actually necessary for us to function.