5 ms·

Nicotine has it uses and benefits. The abuse of that or the "cigarretization" is the problem. One thing is to get real organic tabbaco and smoke in small quan

Nicotine has it uses and benefits. The abuse of that or the "cigarretization" is the problem. One thing is to get real organic tabbaco and smoke in small quantities not inhalling only getting nicotine thru gum line. About the benefits in cognition [1][4] alzheimers and parkinson [2], helping with covid [3] and even testosterone [5] Cigarretes + additives are *very* bad you can see the difference here [6]. Is tobbaco bad? yes. Is nicotine bad maybe. Is cigarrete bad? Yes very Is Cigar bad? Yes but not as cigarrete. TlDr -> Go for pure nicotine or cigars if you need neuroprotection. [1] - https://pubmed.ncbi.nlm.nih.gov/1579636/ https://pubmed.ncbi.nlm.nih.gov/1579636/ [2] - https://pubmed.ncbi.nlm.nih.gov/1859921/ https://pubmed.ncbi.nlm.nih.gov/1859921/ [3] - https://openres.ersjournals.com/content/7/2/00713-2020 https://openres.ersjournals.com/content/7/2/00713-2020 [4] - https://pubmed.ncbi.nlm.nih.gov/9006184/ https://pubmed.ncbi.nlm.nih.gov/9006184/ [5] - https://pubmed.ncbi.nlm.nih.gov/24457405/ https://pubmed.ncbi.nlm.nih.gov/24457405/ [6] - https://pubmed.ncbi.nlm.nih.gov/29459935/ https://pubmed.ncbi.nlm.nih.gov/29459935/

pclark 4y ago
I don't believe in conflating academic debates about the alleged complicated unproven merits of nicotine with the chronic public health policy failure of how the world has regulated cigarettes, vaping and wider nicotine products. Sorry, I don't want my parent comment to be construed as being pro nicotine. If you don't smoke combustible cigarettes don't vape or touch nicotine. I feel a moral burden to be really clear about these topics as someone that briefly worked in this industry.
sithadmin 4y ago
>Is nicotine bad maybe. Minor nootropic effect aside, nicotine is absolutely terrible for the human body. Most people don't realize this because public health campaigns highlighting issues with tobacco products include statements about negative health outcomes caused by nicotine, but neglect to separate these issues from those that are linked to tobacco specifically. Nicotine consumption is linked to: -accelerated tumor growth: https://www.nature.com/articles/nm0701_833 https://www.nature.com/articles/nm0701_833 -vascular calcification: https://onlinelibrary.wiley.com/doi/abs/10.1111/eci.13077 https://onlinelibrary.wiley.com/doi/abs/10.1111/eci.13077 -arteriosclerosis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805015/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805015/ -mutagenesis/various cancers: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363846/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363846/ -reduced alveolar function and bronchoconstriction, miscellaneous pulmonary injury: https://pubmed.ncbi.nlm.nih.gov/3097432/ https://pubmed.ncbi.nlm.nih.gov/3097432/; https://journals.physiology.org/doi/full/10.1152/ajplung.00564.2017 https://journals.physiology.org/doi/full/10.1152/ajplung.005... -peridontal disease: https://onlinelibrary.wiley.com/doi/abs/10.1111/omi.12228 https://onlinelibrary.wiley.com/doi/abs/10.1111/omi.12228
- fsn4dN69ey 4y ago
  >-accelerated tumor growth: https://www.nature.com/articles/nm0701_833 https://www.nature.com/articles/nm0701_833 mouse model >-vascular calcification: https://onlinelibrary.wiley.com/doi/abs/10.1111/eci.13077 https://onlinelibrary.wiley.com/doi/abs/10.1111/eci.13077 review which includes mostly studies on cigarettes >-arteriosclerosis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805015/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805015/ cigarettes >-mutagenesis/various cancers: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363846/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363846/ giant systematic review, going through though it seems most of these are mice studies or studies on smokers (cigarette smokers) >-reduced alveolar function and bronchoconstriction, miscellaneous pulmonary injury: https://pubmed.ncbi.nlm.nih.gov/3097432/ https://pubmed.ncbi.nlm.nih.gov/3097432/; https://journals.physiology.org/doi/full/10.1152/ajplung.005 https://journals.physiology.org/doi/full/10.1152/ajplung.005... first one is cigarettes, second one is a rat model but they actually did design the aerosolized nicotine pretty well >-peridontal disease: https://onlinelibrary.wiley.com/doi/abs/10.1111/omi.12228 https://onlinelibrary.wiley.com/doi/abs/10.1111/omi.12228 cigarettes to really get a concise view, we would want to look at studies of people who only use nicotine gum, or studies of people who use vapes. just be careful blindly posting papers you found from googling "nicotine bad paper" and dig more than 2 seconds into a paper, you can spread a lot of misinformation that way. we all know smoking and cigarettes are bad for you, but are the outside effects primarily from nicotine or from everything surrounding the delivery mechanism of it?

pclark 4y ago

I don't believe in conflating academic debates about the alleged complicated unproven merits of nicotine with the chronic public health policy failure of how the world has regulated cigarettes, vaping and wider nicotine products. Sorry, I don't want my parent comment to be construed as being pro nicotine. If you don't smoke combustible cigarettes don't vape or touch nicotine. I feel a moral burden to be really clear about these topics as someone that briefly worked in this industry.

sithadmin 4y ago

>Is nicotine bad maybe. Minor nootropic effect aside, nicotine is absolutely terrible for the human body. Most people don't realize this because public health campaigns highlighting issues with tobacco products include statements about negative health outcomes caused by nicotine, but neglect to separate these issues from those that are linked to tobacco specifically. Nicotine consumption is linked to: -accelerated tumor growth: https://www.nature.com/articles/nm0701_833 https://www.nature.com/articles/nm0701_833 -vascular calcification: https://onlinelibrary.wiley.com/doi/abs/10.1111/eci.13077 https://onlinelibrary.wiley.com/doi/abs/10.1111/eci.13077 -arteriosclerosis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805015/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805015/ -mutagenesis/various cancers: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363846/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363846/ -reduced alveolar function and bronchoconstriction, miscellaneous pulmonary injury: https://pubmed.ncbi.nlm.nih.gov/3097432/ https://pubmed.ncbi.nlm.nih.gov/3097432/; https://journals.physiology.org/doi/full/10.1152/ajplung.00564.2017 https://journals.physiology.org/doi/full/10.1152/ajplung.005... -peridontal disease: https://onlinelibrary.wiley.com/doi/abs/10.1111/omi.12228 https://onlinelibrary.wiley.com/doi/abs/10.1111/omi.12228

fsn4dN69ey 4y ago
>-accelerated tumor growth: https://www.nature.com/articles/nm0701_833 https://www.nature.com/articles/nm0701_833 mouse model >-vascular calcification: https://onlinelibrary.wiley.com/doi/abs/10.1111/eci.13077 https://onlinelibrary.wiley.com/doi/abs/10.1111/eci.13077 review which includes mostly studies on cigarettes >-arteriosclerosis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805015/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805015/ cigarettes >-mutagenesis/various cancers: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363846/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363846/ giant systematic review, going through though it seems most of these are mice studies or studies on smokers (cigarette smokers) >-reduced alveolar function and bronchoconstriction, miscellaneous pulmonary injury: https://pubmed.ncbi.nlm.nih.gov/3097432/ https://pubmed.ncbi.nlm.nih.gov/3097432/; https://journals.physiology.org/doi/full/10.1152/ajplung.005 https://journals.physiology.org/doi/full/10.1152/ajplung.005... first one is cigarettes, second one is a rat model but they actually did design the aerosolized nicotine pretty well >-peridontal disease: https://onlinelibrary.wiley.com/doi/abs/10.1111/omi.12228 https://onlinelibrary.wiley.com/doi/abs/10.1111/omi.12228 cigarettes to really get a concise view, we would want to look at studies of people who only use nicotine gum, or studies of people who use vapes. just be careful blindly posting papers you found from googling "nicotine bad paper" and dig more than 2 seconds into a paper, you can spread a lot of misinformation that way. we all know smoking and cigarettes are bad for you, but are the outside effects primarily from nicotine or from everything surrounding the delivery mechanism of it?