3 ms·
What would “more foundational research on cures” look like? I do cancer research and, frankly, the work feels pretty foundational. I’m curious what you would ch
by bglazer 4y ago
What would “more foundational research on cures” look like? I do cancer research and, frankly, the work feels pretty foundational. I’m curious what you would change.
Also please note that cancer vaccines have been tried but have failed for a few reasons. First, cancer cells are quite similar to normal cells, so cross reactivity is a problem. So, a typical approach is to to target “neoantigens” which are mutated cell surface proteins that are only on cancer cells. Not all cancers have neoantigens and they can mutate to stop expressing the neoantigen. Also tumors can express proteins that suppress or evade the immune system. PD-L1 blockers target one of the ways tumors do this.
All that to say, it’s not like people aren’t trying this stuff. It’s just really, really hard.