5 ms·
One of the smaller pilot trials mentioned has since posted results (n=33). Valtrex administration over 28 days resulted in a (very?) small improvement to cognit
by ed 4y ago
One of the smaller pilot trials mentioned has since posted results (n=33). Valtrex administration over 28 days resulted in a (very?) small improvement to cognitive scores (MMSE in the paper):
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919248/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919248/
A larger trial (n=130) is expected to complete by December 2023 (it was originally expected to complete around now, but just finished recruiting):
https://beta.clinicaltrials.gov/study/NCT03282916?patient=NCT03282916&locStr=&distance=0&tab=results https://beta.clinicaltrials.gov/study/NCT03282916?patient=NC...
- ncmncm 4y agoI'm taking my valacyclovir periodically, regardless. It might be useless. But it keeps the cold sores down. Got my Tdap, too, because a colossal US Veterans Administration study showed that a recent Tdap booster predicted a 40% reduction in dementia risk. Dunno anything else with that predictive power.
- derbOac 4y agoAcyclovir family meds need to be available over the counter or through a pharmacist. There's actually papers showing that they can be safely taken OTC, and rebuttles basically just saying that "it would set a precedent and increase demand for more meds to be available OTC." To me it's a poster child for the dangers of medication overregulation.
- MassPikeMike 4y agoTopical acyclovir is indeed OTC in Taiwan. A largish tube costs about 7 USD. In the US I needed a prescription for it and that same size tube was a couple of hundred bucks.
- ncmncm 4y agoTopical *cylovir is a weird concept. The virus is inside nerves. Anyway, does acyclovir still work, anywhere?