TLDR; There are lots of types of neurotransmitters and lots of types of neurons, even within the general class of Pyramidal neurons. There seem to be large vari

TLDR; There are lots of types of neurotransmitters and lots of types of neurons, even within the general class of Pyramidal neurons. There seem to be large variations in how and when the types of neurons form and modify synapses (connections) between them. What if there were only a few factors that govern most of that variation? Using computer simulation the authors focus on calcium as a signaling mechanism, the size of synaptic spines, and known behavior of pre and post synaptic structures to create a predictive model of how and when synapses will be modified. They then compare their simulated results and model with results taken from real-world experiments and get good agreement.