That seems particularly important. Leptin is naturally released by fat cells, so I wonder how this would have impacted overweight mice, who may have already bee

That seems particularly important. Leptin is naturally released by fat cells, so I wonder how this would have impacted overweight mice, who may have already been naturally releasing this leptin - assuming that's how leptin works. But also, no one should be fasting and eating nothing - they should make sure they're getting the necessary vitamins and minerals. Taking more leptin could make sense.