This paper here will fill in the gaps of why auto antibodies against GPCR could be a bad thing - initiating autoimmune disease. "GPCRs are the largest superfam

This paper here will fill in the gaps of why auto antibodies against GPCR could be a bad thing - initiating autoimmune disease. "GPCRs are the largest superfamily of integral membrane proteins in humans10. GPCRs play an essential role in vertebrate physiology by sensing the external environment of a cell and responding to a variety of physiological stimuli11. For instance, GPCRs coordinate the cellular behavior involved in host immune responses." " we suspect that the homeostasis of aab relationships, which are possibly a physiological part of our immune system, may break down, causing autoimmune disease." https://www.nature.com/articles/s41467-018-07598-9 https://www.nature.com/articles/s41467-018-07598-9