To be pedantic, the ai/ml approach has no concept of the protein folding process, merely the structural motifs that result when it is complete. These are the X

To be pedantic, the ai/ml approach has no concept of the protein folding process, merely the structural motifs that result when it is complete. These are the X-ray or cryoEM environments used in the training process. The 50-year hunt has been to be able to understand and simulate the dynamics involved in folding itself. This seems so complex to simulate yet nature finds it almost trivial. Protein homology, deriving structures from similar proteins, is the “parent” of this, not molecular dynamics.