4 ms·
Host protease activity classifies pneumonia etiology. Anahar et al. (2022), PNAS https://www.pnas.org/doi/10.1073/pnas.2121778119 https://www.pnas.org/doi/10.1
by hirenj 4y ago
Host protease activity classifies pneumonia etiology. Anahar et al. (2022), PNAS
https://www.pnas.org/doi/10.1073/pnas.2121778119 https://www.pnas.org/doi/10.1073/pnas.2121778119
- hirenj 4y agoSo what they’ve got is a bunch of barcoded synthetic peptides, which they use to assay for protease activity (is there even enough specificity information for each protease?). Based on the signature of activity they fit some model to tell one infection apart from the other. It’s a neat application of their technology (basically barcoded peptides), and I would imagine this reflects tropism of viruses and bacteria, and the different inflammatory responses likely elucidated by the respective cells being damaged.
- cinntaile 4y agoEtiology is just a fancy word to say 'cause' by the way. Maybe you get judged by your scientific peers if you use words everybody understands, who knows.