I find the other trade off (against the extra fuel consumption from each takeoff and climb) interesting. Additional fuel is consumed to carry the weight of the

I find the other trade off (against the extra fuel consumption from each takeoff and climb) interesting. Additional fuel is consumed to carry the weight of the additional fuel required for a longer range (and so that is recursive). For example, under the Weight - Flight Distance heading of the Fuel Economy in Aircraft Wikipedia page, it notes that for trips above 3000 NM, it is more efficient for a 777-300 to make a stop for refuelling. https://en.m.wikipedia.org/wiki/Fuel_economy_in_aircraft https://en.m.wikipedia.org/wiki/Fuel_economy_in_aircraft