5 ms·

I had treatment 100 mg 21 days BID for borreliosis and was careful to always take with a full glass of water, as directed. Only noticeable side effect was affec

by bregma 4y ago

I had treatment 100 mg 21 days BID for borreliosis and was careful to always take with a full glass of water, as directed. Only noticeable side effect was affect changes. 9/7 would take that drug again.

erisinger 4y ago
Can you elaborate on affect changes? I had a similar regimen and experienced a weird sense of mental clarity and sociability for a couple of weeks after. Never have figured out what the mechanism was.
- bregma 4y ago
  Positive affect changes are a noted possible side effect. The mechanism is unknown. Some scientists believe it's the direct action of the drug on the brain, but others believe it has something to do with altering the natural intestinal flora and a vague "gut-brain connection". It's an area of research waiting to be tackled. I wasn't going to complain about feeling better than normal, only a little disappointed after the scrip ran out.
  - lostlogin 4y ago
    > the scrip ran out. Assuming that was written intentionally, I had no idea that this was a word, and that this was a usage. I’ve learned something.
    - jrumbut 4y ago
      It should be "script" I believe, short for "prescription". Scrip is a word, but its meaning is different and it's close to archaic.
      - waqf 4y ago
        Interesting, why do you perceive that "scrip" cannot be short for "prescription" whereas "script" can be? FWIW, Wiktionary lists both: https://en.wiktionary.org/wiki/scrip#Etymology_4 https://en.wiktionary.org/wiki/scrip#Etymology_4
      - WalterGR 4y ago
        People in medicine use "scrip" to mean "prescription" when speaking to others in the field.
  - erisinger 4y ago
    Interesting. Do you have a source for that? I had hypothesized that the antibiotics were either giving my immune system a boost which was tamping down some underlying inflammation somewhere, or were helping fight some intestinal flora that normally cause some subtle mood effects that I wouldn’t normally notice until it was absent. But I was never able to find anything online to pin it down one way or the other.
- johnnymorgan 4y ago
  Look into suramin, pax101 to be specific. It's being used to treat autism symptoms (social). Might be a similar mechanism
nerdponx 4y ago
When I had Lyme disease, I needed to take it with a full meal, otherwise I was in for a half hour of horrible burning pain.

by bregma 4y ago

erisinger 4y ago

Can you elaborate on affect changes? I had a similar regimen and experienced a weird sense of mental clarity and sociability for a couple of weeks after. Never have figured out what the mechanism was.

bregma 4y ago
Positive affect changes are a noted possible side effect. The mechanism is unknown. Some scientists believe it's the direct action of the drug on the brain, but others believe it has something to do with altering the natural intestinal flora and a vague "gut-brain connection". It's an area of research waiting to be tackled. I wasn't going to complain about feeling better than normal, only a little disappointed after the scrip ran out.
- lostlogin 4y ago
  > the scrip ran out. Assuming that was written intentionally, I had no idea that this was a word, and that this was a usage. I’ve learned something.
  - jrumbut 4y ago
    It should be "script" I believe, short for "prescription". Scrip is a word, but its meaning is different and it's close to archaic.
    - waqf 4y ago
      Interesting, why do you perceive that "scrip" cannot be short for "prescription" whereas "script" can be? FWIW, Wiktionary lists both: https://en.wiktionary.org/wiki/scrip#Etymology_4 https://en.wiktionary.org/wiki/scrip#Etymology_4
    - WalterGR 4y ago
      People in medicine use "scrip" to mean "prescription" when speaking to others in the field.
- erisinger 4y ago
  Interesting. Do you have a source for that? I had hypothesized that the antibiotics were either giving my immune system a boost which was tamping down some underlying inflammation somewhere, or were helping fight some intestinal flora that normally cause some subtle mood effects that I wouldn’t normally notice until it was absent. But I was never able to find anything online to pin it down one way or the other.
johnnymorgan 4y ago
Look into suramin, pax101 to be specific. It's being used to treat autism symptoms (social). Might be a similar mechanism

nerdponx 4y ago

When I had Lyme disease, I needed to take it with a full meal, otherwise I was in for a half hour of horrible burning pain.