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The brain runs fine off ketones. Better than on glucose, in many cases. This is why so many of the therapeutic targets of ketogenesis are neurological. Only re

by wyager 4y ago

The brain runs fine off ketones. Better than on glucose, in many cases. This is why so many of the therapeutic targets of ketogenesis are neurological. Only red blood cells and a couple other actually need glucose.

JamesBarney 4y ago
I'm not so certain a ketogenic diet is healthy. The Inuit who have been eating an almost entirely ketogenic diet for centuries can't effectively produce ketones. The ability to produce ketones was selected our of their population. I think nature might know something we don't know.
- thebigspacefuck 4y ago
  What do they produce instead?
- whb07 4y ago
  I do not know what you’re referring to, perhaps some supporting data would help. The current method of testing for ketones is ketones freely available in blood stream. The ketones are released by the liver when it’s too full of them and thus they spill over to the blood stream. The consequence therefore is that once you’re fully keto adapted, your ketones won’t spike too high as your body can efficiently generate the required amount. Most people who do a long fast, they’ll have 1+mmol (higher at 3+) ketones, whereas someone who’s adapted maintains sub 1mmol. Also, if all you’re eating is protein and large fats, youre producing ketones otherwise you’d die as there’s no carbs/glucose. So yeah, Inuit and carnivore diet people couldn’t exist. live experiments and observations are a thing, and they are happening everywhere if you do a quick search
  - JamesBarney 4y ago
    They have a defective CPT1A enzyme so they're body can't produce ketones very well. It lead to a high infant mortality, but despite that has been selected for in Inuit populations.
    - wyager 4y ago
      This paper contests the notion that this has to do with possible negative side effects of prolonged ketosis: https://pubmed.ncbi.nlm.nih.gov/32088118/ https://pubmed.ncbi.nlm.nih.gov/32088118/
- mbrodersen 4y ago
  The keto diet is one of the most studied diets in the world. It is super healthy (when done right of course like anything else). The “low carb down under” YouTube group has a lot of talk on the latest research.

by wyager 4y ago

JamesBarney 4y ago

I'm not so certain a ketogenic diet is healthy. The Inuit who have been eating an almost entirely ketogenic diet for centuries can't effectively produce ketones. The ability to produce ketones was selected our of their population. I think nature might know something we don't know.

thebigspacefuck 4y ago
What do they produce instead?
whb07 4y ago
I do not know what you’re referring to, perhaps some supporting data would help. The current method of testing for ketones is ketones freely available in blood stream. The ketones are released by the liver when it’s too full of them and thus they spill over to the blood stream. The consequence therefore is that once you’re fully keto adapted, your ketones won’t spike too high as your body can efficiently generate the required amount. Most people who do a long fast, they’ll have 1+mmol (higher at 3+) ketones, whereas someone who’s adapted maintains sub 1mmol. Also, if all you’re eating is protein and large fats, youre producing ketones otherwise you’d die as there’s no carbs/glucose. So yeah, Inuit and carnivore diet people couldn’t exist. live experiments and observations are a thing, and they are happening everywhere if you do a quick search
- JamesBarney 4y ago
  They have a defective CPT1A enzyme so they're body can't produce ketones very well. It lead to a high infant mortality, but despite that has been selected for in Inuit populations.
  - wyager 4y ago
    This paper contests the notion that this has to do with possible negative side effects of prolonged ketosis: https://pubmed.ncbi.nlm.nih.gov/32088118/ https://pubmed.ncbi.nlm.nih.gov/32088118/
mbrodersen 4y ago
The keto diet is one of the most studied diets in the world. It is super healthy (when done right of course like anything else). The “low carb down under” YouTube group has a lot of talk on the latest research.