5 ms·

The problem with glucosamine is that it reliably increases intraocular pressure. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350357/ https://www.ncbi.nlm.nih

• agumonkey 4y ago
  Is there research to engineer ways so that we can use blood as delivery only in some areas ? I know it sounds stupid but maybe toying with timings so that chemicals never live long enough to reach upper body / brain ? or maybe microcapsules that only dissolve in certain biological environment ?
  • db65edfc7996 4y ago
    Specifically targeting compounds is an active area of research. Example: all oncotherapies are essentially just poison. The trick is to deliver the toxin to the 0.001% of cells in the body that are cancerous. It is amusing you should say ways that avoid reaching the brain. The blood-brain barrier impedes a large number of therapeutics from entering the brain. It is incredibly difficult to engineer the constraints of something that: is potent enough to have an effect, can survive in the blood, cross into the brain, targets the cells of interest, has a meaningful half-life, does not decompose into something toxic, etc.
• voisin 4y ago
  Does it raise it enough to cause issues? What are the issues associated with increased pressure?
  • manceraio 4y ago
    Increases the risk of glaucoma. https://www.nei.nih.gov/learn-about-eye-health/eye-conditions-and-diseases/glaucoma/glaucoma-and-eye-pressure#:~:text=Research%20shows%20that%20high%20eye,stop%20vision%20loss%20from%20glaucoma https://www.nei.nih.gov/learn-about-eye-health/eye-condition....
  • aaaaaaaaaaab 4y ago
    Literally the first Google result for "eye pressure" is about glaucoma. So go figure.