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Considering stimulants (generally, but also specific ones) only work for a portion of people that try it, I find this very unsurprising. The increase isn't that

Considering stimulants (generally, but also specific ones) only work for a portion of people that try it, I find this very unsurprising. The increase isn't that big and probably down to a mixture of disappointment and side effects without the main effects. It's one of the main reasons doctors prescribe different stimulants. I've personally heard every mutation of "This one worked for me but the other one gave me bad side effects and little effect".

kayodelycaon 4y ago
The study is useful as something to watch for when using medication, not for avoiding medication. We already know starting antidepressants has an increased suicide risk.
- sascha_sl 4y ago
  Do I really seem so defensive? I really didn't mean to... I of course know that this is how it's meant to be used. But having gone through ADHD and trans healthcare I know everything that looks like ammo will be used as ammo. Even the things that explicitly state they are not ammo. By healthcare professionals and those that want to enact change on a higher level.
  - kayodelycaon 4y ago
    I was attempting to add on what you were saying. :)
jimmygrapes 4y ago
You'd think by now we would have some way to test the concentration of various things (serotonin, norepinephrine, etc.) in the body BEFORE issuing medications that might modify them, and then measure such concentrations afterwards to get a better idea of what to use, rather than the current "try different things and rely solely on the subjective description provided by the (likely untrained and inarticulate) test subject." Or maybe we do and I've never been privy to this knowledge nor provided such a test.
- kayodelycaon 4y ago
  The problem is neurotransmitters are signaling devices, there are no "levels". There are only differences in reactivity to signals that differ all over the brain. It would be like trying to tracks cars by only observing traffic lights.
- 331c8c71 4y ago
  Looks like the existing methods for measuring neurotrasmitter concentrations in the brain are pretty invasive, e.g. electrodes at best and the analysis of extracted tissue at worst. And I am not sure whether blood concentrations are indicative of anything.

kayodelycaon 4y ago

The study is useful as something to watch for when using medication, not for avoiding medication. We already know starting antidepressants has an increased suicide risk.

sascha_sl 4y ago
Do I really seem so defensive? I really didn't mean to... I of course know that this is how it's meant to be used. But having gone through ADHD and trans healthcare I know everything that looks like ammo will be used as ammo. Even the things that explicitly state they are not ammo. By healthcare professionals and those that want to enact change on a higher level.
- kayodelycaon 4y ago
  I was attempting to add on what you were saying. :)

jimmygrapes 4y ago

You'd think by now we would have some way to test the concentration of various things (serotonin, norepinephrine, etc.) in the body BEFORE issuing medications that might modify them, and then measure such concentrations afterwards to get a better idea of what to use, rather than the current "try different things and rely solely on the subjective description provided by the (likely untrained and inarticulate) test subject." Or maybe we do and I've never been privy to this knowledge nor provided such a test.

kayodelycaon 4y ago
The problem is neurotransmitters are signaling devices, there are no "levels". There are only differences in reactivity to signals that differ all over the brain. It would be like trying to tracks cars by only observing traffic lights.
331c8c71 4y ago
Looks like the existing methods for measuring neurotrasmitter concentrations in the brain are pretty invasive, e.g. electrodes at best and the analysis of extracted tissue at worst. And I am not sure whether blood concentrations are indicative of anything.