Some antipsychotics work by essentially blocking the activation of most neurotransmitter receptors, preventing neural circuits from firing. Newer ones also acti

Some antipsychotics work by essentially blocking the activation of most neurotransmitter receptors, preventing neural circuits from firing. Newer ones also activate one or two specific receptors. It seems plausible that these two ”frames of mind” are two completely separate neuronal networks, and because one of them is entirely blocked while on medication, it tends to overfire when off medication.