I would say that deno vs node is the biggest difference, with node you need to setup and maintain 3rd party tools (bundlers, transpilers, etc) but with deno all

I would say that deno vs node is the biggest difference, with node you need to setup and maintain 3rd party tools (bundlers, transpilers, etc) but with deno all that tooling is first party, so in theory is less things to install and worry about. Deno has other advantages in paper, like official ts support, all the tooling was written in rust (so it's more performant that the default ones that the others use). The only downside right now with deno is popularity and maturity of the ecosystem, it is just too new, so you will have hard time finding what you are looking for that works out of the box, while a lot of companies invested in node official packages.