2 ms·
Thanks, good to know about pericarditis. I’m not well versed on that or myocarditis and in particular the IgG or T-Cell response mechanism. Though the little I’
by elcritch 4y ago
Thanks, good to know about pericarditis. I’m not well versed on that or myocarditis and in particular the IgG or T-Cell response mechanism. Though the little I’ve read seems to indicate myocarditis is still primarily due to an acute immune response, but can re-occur or turn into a more autoimmune condition (chromic myocarditis or perhaps pericarditis).
That said I would normally give the benefit of doubt that the authors of a paper in the Lancet are more well versed on myocarditis and it’s behavior. It looks like they do adjust all their comparisons to odds ‘per 100,000 person-days’. If done properly that would adjust from an event basis to per-time basis or rate which could account for long tail reactions.
Using 90 days would risk including non-vaccine related myocarditis risks as well, which is perhaps why the lancet paper uses the time rate basis. If someone got a normal cold after a month and got pericarditis that'd skew the results as an example. Though I was disappointed to not see statistical analysis or comparison to normal occurrence rates of myocarditis without vaccine exposure, etc. though I didn’t thoroughly check their references, etc.