3 ms·

not a biologist by any mean, but i think location is very important, especially for an air transmitted disease like covid : mouth / nose / lungs are all part of

by bsaul 4y ago

not a biologist by any mean, but i think location is very important, especially for an air transmitted disease like covid : mouth / nose / lungs are all part of the "outside" of your body, aka the mucosa. That's probably where the largest part of the infection takes place in the case of a natural covid infection. Vaccines otoh enters your bloodstream and may result in infection everywhere in your body, touching many places that wouldn't be by a natural contamination process. (disclaimer : please correct me if i'm wrong, and in all case never take medical advices from random people online)

hijodelsol 4y ago
This is not really true, vaccines first and foremost enter cells at the point of injection (intramuscular) through fusion of the lipid nano particles with the cell membrane, not via the ACE2 or TMPRSS route as the live virus. The immune response then depends on the migration of antigen presenting cells to the mostly peripheral lymph nodes where the full immune response is mounted including germinal centers. This has little to do with blood borne propagation. The virus on the other hand has multiple ways of entry into cells, ACE2 dependent, the endosomal route, syncytia formation and others that are still discussed. What is not up for debate though is that SARS-CoV-2 regularly infects other organs, including the kidney [1] and the liver were it does damage. It has also been shown to persist in organs like the intestine for more than a year in its live form. Due to the (super-)antigenic nature of the virus and the subsequent systemic inflammatory response the rate of post-Covid myocarditis also by far exceeds the incidence of myocarditis after vaccination in all age groups and cases tend to be more severe with the virus. It will be important to develop mucosal vaccines because current vaccines only elicit a very limited and short-lived IgA response and IgA antibodies, thanks to their shape, confer protection without excessive inflammation and offer protection against infection. But your description of the spread of the virus and the vaccine is just not accurate. 1: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31759-1/fulltext https://www.thelancet.com/journals/lancet/article/PIIS0140-6...
- bsaul 4y ago
  thanks for the clarification. I think to have read that vaccine was in fact observed spreading much further than expected, reaching organs everywhere. Since you seem knowledgeable, can you confirm ?

by bsaul 4y ago

hijodelsol 4y ago

This is not really true, vaccines first and foremost enter cells at the point of injection (intramuscular) through fusion of the lipid nano particles with the cell membrane, not via the ACE2 or TMPRSS route as the live virus. The immune response then depends on the migration of antigen presenting cells to the mostly peripheral lymph nodes where the full immune response is mounted including germinal centers. This has little to do with blood borne propagation. The virus on the other hand has multiple ways of entry into cells, ACE2 dependent, the endosomal route, syncytia formation and others that are still discussed. What is not up for debate though is that SARS-CoV-2 regularly infects other organs, including the kidney [1] and the liver were it does damage. It has also been shown to persist in organs like the intestine for more than a year in its live form. Due to the (super-)antigenic nature of the virus and the subsequent systemic inflammatory response the rate of post-Covid myocarditis also by far exceeds the incidence of myocarditis after vaccination in all age groups and cases tend to be more severe with the virus. It will be important to develop mucosal vaccines because current vaccines only elicit a very limited and short-lived IgA response and IgA antibodies, thanks to their shape, confer protection without excessive inflammation and offer protection against infection. But your description of the spread of the virus and the vaccine is just not accurate. 1: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31759-1/fulltext https://www.thelancet.com/journals/lancet/article/PIIS0140-6...

bsaul 4y ago
thanks for the clarification. I think to have read that vaccine was in fact observed spreading much further than expected, reaching organs everywhere. Since you seem knowledgeable, can you confirm ?