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There’s not any type of mapping and this is what makes biology so difficult to study and understand. One gene can affect anywhere from zero other genes to every
by axg11 4y ago
There’s not any type of mapping and this is what makes biology so difficult to study and understand. One gene can affect anywhere from zero other genes to every single gene. We also need to account for effects at every level of the central dogma of biology. Knockout of a gene can affect genetics, RNA, protein, and much more we don’t even know about yet. The other underestimated complicating factor is that biology is very nonlinear. A 10% increase in gene expression could lead to no resulting effect, whereas an 11% increase in expression could upregulate downstream genes by 1000x.
- hgomersall 4y agoI remember going to a really interesting talk in which the proposal was to represent the transcriptome as a probabilistic generative model. That felt like getting something close to an appreciation of the complexity.