Personally, I use and recommend https://github.com/ShamariFeaster/chrome-extension-hn-filter/ https://github.com/ShamariFeaster/chrome-extension-hn-filter...

Personally, I use and recommend https://github.com/ShamariFeaster/chrome-extension-hn-filter/ https://github.com/ShamariFeaster/chrome-extension-hn-filter... which allows you to set keywords (and domains) to automatically hide on the main feed. Actually useful keywords vary over time, so this is something you have to curate manually, but saved me a lot of attention so far.