Set up a straight forward division of labor. Government serves as incubator, funding basic research, early stage trials, angel investor for promising teams. Go

Set up a straight forward division of labor. Government serves as incubator, funding basic research, early stage trials, angel investor for promising teams. Govt then auctions rights to productize drugs. Industry pays govt a royalty. Modulate the royalty to incentivize desired outcomes. eg zero (or negative) royalty for malaria, 3000% for esteem remedies like viagra. Further, when there is no market demand for obvious public health priorities, govt contracts with industry, paying for mfg, distribution, marketing, training, whatever.