you should use NIfTI, which is the de facto standard for 3D medical imaging. not compressed, but handles the voxel-image space transform which is far far more

you should use NIfTI, which is the de facto standard for 3D medical imaging. not compressed, but handles the voxel-image space transform which is far far more important and quite complicated. you can slap gzip on top of it and most libraries/FIJI will transparently decompress