The best explanation I’m aware of for the disproportionate death rates by Europeans vs Native Americans by disease is mainly population density of European citi

The best explanation I’m aware of for the disproportionate death rates by Europeans vs Native Americans by disease is mainly population density of European cities was dramatically higher, leading to a lot of diseases that would permanently spread throughout the population until the combination of evolution and immune systems brought it to a symbiotic, fairly neutral relationship. Which didn’t remain so neutral when applied to fresh populations. Native Americans simply weren’t playing host to as many diseases, and persisting virulent ones