3 ms·

I am not sure the two are comparable given that LSD does not function on dopaminergic circuits.

• monocasa 4y ago
  https://pubmed.ncbi.nlm.nih.gov/27544651/ https://pubmed.ncbi.nlm.nih.gov/27544651/
  • PartiallyTyped 4y ago
    That's because serotonin circuits (where LSD and magic mushrooms act on) are antagonists to dopaminergic circuits [1]. [1] https://moleculeofmore.com/ https://moleculeofmore.com/
    • monocasa 4y ago
      What you've described is a mechanism for functioning on dopaminergic circuits.
  • bgandrew 4y ago
    so it's like comparing a downer to an upper, right? not the best comparison in my books.
    • PartiallyTyped 4y ago
      LSD is not exactly a downer. The decreased activity is because serotonin circuits are antagonists to dopamine circuits.
      • bgandrew 4y ago
        I know. I'm just saying there is very little sense in comparing it to adderall.
        • sva_ 4y ago
          I think you can compare it to amphetamines (adderall): Amphetamines narrow your focus of attention, while psychdelics widen it.
          • celdon25 4y ago
            > Amphetamines narrow your focus of attention, while psychdelics widen it. And that's exactly why this study is bogus. Here are the two tests which they used to "measure" cognitive ability. See anything wrong here? https://en.wikipedia.org/wiki/Digit_symbol_substitution_test https://en.wikipedia.org/wiki/Digit_symbol_substitution_test https://en.wikipedia.org/wiki/N-back https://en.wikipedia.org/wiki/N-back
• eurasiantiger 4y ago
  Where do you get that from? In addition to its serotonergic effects, LSD is a D3, D4, D2 and D1 receptor agonist. https://upload.wikimedia.org/wikipedia/en/2/20/LSDaffinities.GIF https://upload.wikimedia.org/wikipedia/en/2/20/LSDaffinities...