3 ms·
Also not expert.. I was looking around for the precursors and found that Ribose has been detected in meteorites[1]. That seems to leave finding prebiotic sourc
by pmayrgundter 4y ago
Also not expert.. I was looking around for the precursors and found that Ribose has been detected in meteorites[1]. That seems to leave finding prebiotic sources of the nucleobases, purine and pyrimidine.[2] Seems this is known, tho haven't seen a natural catalytic pathway to combine them into a nucleoside.
Purine can be synthesized from Formamide via simple heating[3], and Formamide is common enough that it's hypothesized as an alternative to water, for a universal solvent in exobiology.[4,5]
So, easy enough! ;)
As remarked in sibling, it seems the harder step is the energetic bump up to a triphosphate.
[1] https://en.wikipedia.org/wiki/Ribose https://en.wikipedia.org/wiki/Ribose
[2] https://en.wikipedia.org/wiki/Nucleobase https://en.wikipedia.org/wiki/Nucleobase
[3] https://en.wikipedia.org/wiki/Purine#Laboratory%20synthesis https://en.wikipedia.org/wiki/Purine#Laboratory%20synthesis
[4,5] https://en.wikipedia.org/wiki/Formamide https://en.wikipedia.org/wiki/Formamide
https://en.wikipedia.org/wiki/Hypothetical_types_of_biochemistry#Non-water%20solvents https://en.wikipedia.org/wiki/Hypothetical_types_of_biochemi...