2 ms·

I read this a lot. But I've also read the opposite: that it's hard to find effects demonstrated in smaller mammals that don't also hold in humans. What are exa

• NonNefarious 4y ago
  Resveratrol? That was supposed to be a big fountain of youth, but has flopped spectacularly.
• Rury 4y ago
  Often drug studies, such as in the case of Fialuridine. Showed excellent results in animal studies (including mice, rats, dogs, and primates) with no ill effects, but ended up being fatally toxic for humans. Turned out it was toxic in humans because a specific protein on the surface of our mitochondria would move it inside our mitochondria, where it would poison/destroy our mitochondria. This didn't happen in the animal studies (even though they have the same protein), because 3 DNA mutations caused the gene encoding the protein to be just different enough, that it would prevent it from being able to transport the drug into their cell’s mitochondria. Now that said, just because one promising animal study failed to work for humans, doesn't mean they all will fail. A lot of animal studies do in fact also hold for humans. It's just that, one shouldn't jump to conclusions either which way.