Oh, you'd lose a challenge certainly but you'd have many more remaining besides. Biters provide a nice clock for advancing your base by forcing you to progress

Oh, you'd lose a challenge certainly but you'd have many more remaining besides. Biters provide a nice clock for advancing your base by forcing you to progress your military industrial complex, but like all Factorio problems you solve it by automating the solution. I think the presence or absence of biters changes the game less than choosing between default worldgen and train worlds.