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The text says "They point out that, based on their peptide sequences, both precursors are likely to be secreted molecules." How can they tell that from the sequ
by ddabed 4y ago
The text says "They point out that, based on their peptide sequences, both precursors are likely to be secreted molecules." How can they tell that from the sequence?
- fredgrott 4y agoMy bias, attempted a Molecular MS at Purdue. Probably due to small weight and size as being near other known secreted moelcules.
- ddabed 4y agoThanks a lot!, I though something similar but wasn't sure because while the neuropeptides are phoenixin and nesfatin the sequences are for the precursors SMIM20 and NUCB2 and maybe they could be a lot bigger although makes more sense if neuropeptides and precursors are close in size certainly.
- flobosg 4y agoProteins that will be secreted have, usually at the beginning of their sequence, a signal motif (or “signal peptide”) that is recognized by the secretory machinery of the cell. The presence of the signal peptide in a protein can be predicted by computational methods such as SignalP (https://www.nature.com/articles/s41587-021-01156-3 https://www.nature.com/articles/s41587-021-01156-3). That’s what the authors did in the paper.
- ddabed 4y agoThanks a lot!, actually tried adding this on wikipedia (https://en.wikipedia.org/wiki/Evolution_of_nervous_systems#Neural_precursors https://en.wikipedia.org/wiki/Evolution_of_nervous_systems#N...) because seemed important enough so I really looked at the paper and read about the signal peptide but clearly didn't understand it was the relevant element.