I think the font size is the most obtrusive to begin with - it's just insanely huge. I'm a Web 2.0 fan as much as the next guy and think most websites use a fon

I think the font size is the most obtrusive to begin with - it's just insanely huge. I'm a Web 2.0 fan as much as the next guy and think most websites use a font size that is to small but... ouch. I think that would be a good place to start - once you do that you may find that the mouseovers are distracting or jump around way to much now that your line-heights are smaller. Jury seems to be out on those, personally I'm not a fan but enough people said they do like them that it's a questionable change. I think limiting the use of mouseovers could be valuable. By making off-site links (the actual SERPs) not have a mouseover while making in-site links (narrowing of categories, the more... link to activate BOSS, etc) could offer a subconcious identifier to your users as to what the next action will actually do.