So the next stages here are clearly to add functional costs (time, space, equipment) to the reactions and obtain a similar database of supply chain costs and le

So the next stages here are clearly to add functional costs (time, space, equipment) to the reactions and obtain a similar database of supply chain costs and legal hassle for obtaining reactants at various volumes then you can objectively predict with high confidence interval projected market returns on various syntheses. Thus, should a given reactant become expensive or unavailable this would immediately result in a plethora of novel alternate paths. Of course, our entire global economic system is heavily weighted against doing something so useful in public, for the public good...