3 ms·

It is extremely important to understand that the test referenced here, a non-invasive cell free test, is a screening test and not a diagnostic test. Screening t

by abcc8 4y ago

It is extremely important to understand that the test referenced here, a non-invasive cell free test, is a screening test and not a diagnostic test. Screening tests are used to flag individuals for follow-up testing via one of several diagnostic methods. False positives (and false negatives) are expected in this context. I don't think that jumping to conclusions regarding eugenics is at all warranted when discussing this screening test.

philsnow 4y ago
> non-invasive cell free test From the article: > The initial process of polygenic embryo testing looks pretty comparable to the single-gene tests that have been around much longer. First, cells are drawn from an embryo a few days old, and the DNA is processed. Am I looking at the correct test from the article? To my knowledge, any test or procedure that involves piercing the amniotic sac, as this one does, carries around a 4% (additional) risk of miscarriage. I'm in a HN out-crowd that doesn't accept those odds in exchange for possibly-incorrect information about the fetus.
- sinenomine 4y ago
  There is a noninvasive embryo screening method which involves sequencing of culture medium: https://www.pnas.org/doi/10.1073/pnas.1613294113 https://www.pnas.org/doi/10.1073/pnas.1613294113 Thus the risk is avoidable.
- throwasasldk 4y ago
  > I'm in a HN out-crowd that doesn't accept those odds in exchange for possibly-incorrect information about the fetus. Are you? A 1:25 chance of miscarrage for a screening test seems very high. Your question still stands about whether this is piercing the amniotic sac.
  - mensetmanusman 4y ago
    You might be misunderstanding what they mean, as it appears you are on the exact same page…
  - philsnow 4y ago
    In my experience [0], doctors overwhelmingly recommend amniocentesis because it can be used to screen for a number of genetic issues and "wouldn't you want to know?" [0] all of my experience is with a certain HMO provider that seems to regard pregnancy as a dangerous condition, and every time my wife gave birth in their hospital, one of their first questions during the follow-up appointment is either "how are we going to prevent this from happening again?" or just "so you know how birth control works, right?"
    - mensetmanusman 4y ago
      When I was at MIT, my wife’s circle of “moms- / moms-to-be group” was mostly white/asian but had one latino. They had a similar experience with on-campus health of being pushed the “how can we stop this from happening again” messaging from the nurses during routine checkins. I explicitly remember how shocked they were that only the latino was repeatedly asked if she wanted an abortion every time she had checkups. These cultural selection pressures are fascinating, esp. in places like NY city where a majority of conceptions do not end in a successful pregnancy in the black community.

by abcc8 4y ago

philsnow 4y ago

> non-invasive cell free test From the article: > The initial process of polygenic embryo testing looks pretty comparable to the single-gene tests that have been around much longer. First, cells are drawn from an embryo a few days old, and the DNA is processed. Am I looking at the correct test from the article? To my knowledge, any test or procedure that involves piercing the amniotic sac, as this one does, carries around a 4% (additional) risk of miscarriage. I'm in a HN out-crowd that doesn't accept those odds in exchange for possibly-incorrect information about the fetus.

sinenomine 4y ago
There is a noninvasive embryo screening method which involves sequencing of culture medium: https://www.pnas.org/doi/10.1073/pnas.1613294113 https://www.pnas.org/doi/10.1073/pnas.1613294113 Thus the risk is avoidable.
throwasasldk 4y ago
> I'm in a HN out-crowd that doesn't accept those odds in exchange for possibly-incorrect information about the fetus. Are you? A 1:25 chance of miscarrage for a screening test seems very high. Your question still stands about whether this is piercing the amniotic sac.
- mensetmanusman 4y ago
  You might be misunderstanding what they mean, as it appears you are on the exact same page…
- philsnow 4y ago
  In my experience [0], doctors overwhelmingly recommend amniocentesis because it can be used to screen for a number of genetic issues and "wouldn't you want to know?" [0] all of my experience is with a certain HMO provider that seems to regard pregnancy as a dangerous condition, and every time my wife gave birth in their hospital, one of their first questions during the follow-up appointment is either "how are we going to prevent this from happening again?" or just "so you know how birth control works, right?"
  - mensetmanusman 4y ago
    When I was at MIT, my wife’s circle of “moms- / moms-to-be group” was mostly white/asian but had one latino. They had a similar experience with on-campus health of being pushed the “how can we stop this from happening again” messaging from the nurses during routine checkins. I explicitly remember how shocked they were that only the latino was repeatedly asked if she wanted an abortion every time she had checkups. These cultural selection pressures are fascinating, esp. in places like NY city where a majority of conceptions do not end in a successful pregnancy in the black community.