3 ms·
As far as I can tell, no therapy has been successful in removing or preventing specifically either or both of beta and tau amyloid without secondary effects th
by phnofive 4y ago
As far as I can tell, no therapy has been successful in removing or preventing specifically either or both of beta and tau amyloid without secondary effects that washed out any prospective benefit.
The amyloid hypothesis is of course disputed, but largely because stopping whatever causes plaque formations could prevent or lessen the impact of Alzheimer's has proven so difficult and would ultimately provide little benefit to those already suffering with the disease.
- phnofive 4y agoThe closest we've come to removing plaques, I should mention, is aducanumab, which does seem to reduce beta, but has little to no effect on even slowing cognitive decline, much less stopping or reversing it. Nonetheless, the FDA has approved this drug, paving the way for Biogen to charge $56K a year for the treatment. https://n.neurology.org/content/98/15/619 https://n.neurology.org/content/98/15/619