Starcraft 2. Only partially joking. The story continuation was such a letdown I personally consider it not-yet-made. That's probably not what you wanted, but

Starcraft 2. Only partially joking. The story continuation was such a letdown I personally consider it not-yet-made. That's probably not what you wanted, but in slightly similar vein, the indie title "Unepic" had a very neat collection of mechanics and skills which were largely left untapped due to what seems to have been the developer failing in patience/endurance in the second half. One of those features was a quite extensive ability to put things on keybindings. Which brings me to my only suggestion which might actually be on topic: What if you were to put a lot of effort into making the interface easy to customize, deeply, preferably live. Then you'd push the players to use it, possibly creating something of a game mechanism in coping with disparate tasks in the process. Also encourage publishing and forking. I'm not sure it even matters much whether it's a global defense simulator, platformer or sim (and indeed, why not all of them and more), but I'd be very interested to see what it evolves into.