4 ms·

>Title is misleading - this is a first in human, safety/dose-escalation study for this particular oncolytic virus. Thanks for this... it's to the point I rarel

>Title is misleading - this is a first in human, safety/dose-escalation study for this particular oncolytic virus. Thanks for this... it's to the point I rarely read articles about medical studies, because I lack the domain knowledge to evaluate them, and if I just look at the study methodology people get angry when I often notice said methods aren't super stringent. (You can get away with that in psychology, but it's really jarring when I see the same patterns in the physical sciences.)

boppo1 4y ago
You shouldn't be able to get away with it in psychology
- dontbenebby 4y ago
  > You shouldn't be able to get away with it in psychology Then next time you find a study you don't like, contact the IRB[1] that authorized it and contact your representative in Congress[2]. They publish the grant information. Say you'd prefer to receive that money instead, or that it be directed to a more ethical and useful primary investigator. [1] https://en.wikipedia.org/wiki/Institutional_review_board#United_States_mandate_for_IRBs https://en.wikipedia.org/wiki/Institutional_review_board#Uni... [2]https://www.congress.gov/members/find-your-member https://www.congress.gov/members/find-your-member
  - boppo1 4y ago
    This is helpful, thanks!
    - dontbenebby 4y ago
      No problem, but when you speak to your elected representative, please also say that they should have local police adopt a policy that all police officers carry business officers with detailed contact information. At the meta level if someone "gives me a card" and it's just... the phone number to whoever gatekeeps access to them and an email some assistant monitors, then don't expect the same level of trust, deference, or respect as someone like me who hands out the email tied to their real name, the phone number for the SIM in their phone, and the Signal number tied to the phone number they've held onto since they were 16. (You might notice some of my more recent posts seemed rushed, or erratic. That is because I was posting like a literal dissident: drafting things, posting, then immiedately changing locations. A lot of the rhetoric around "community standards" of speech is more about things like, well, yeah, someone might stand up a server with Mein Kampf or something on it, and that's ok because sometimes people want to read that for academic reasons. Anyways sorry for the wall of text, but when folks spoke to me informally, when I was debating certain roles or... companies... a lot of them spoke of things like "analysis paralysis"[1][2] I see a lot of people nowadays who seem to take the view that if they prominently display a contact phone number and unique identifier, they can move to more of a model where anti-social behavior is the default, and challenge others to report out to some... entity... to come and deal with the issue. (Versus making a good faith effort to follow the guidlines, and being willing to accept sincere feedback.) Anyways sorry to wall of text you, but it's been really interesting seeing how people react to me versus others on the internet, especially when I take a long pause from posting here on the orange website ;-) [1] https://web.archive.org/web/20150921200100/https://theintercept.com/2015/05/28/nsa-officials-privately-criticize-collect-it-all-surveillance/ https://web.archive.org/web/20150921200100/https://theinterc... [2] https://web.archive.org/web/20150723204817mp_/https://www.documentcloud.org/documents/2088983-too-many-choices.html https://web.archive.org/web/20150723204817mp_/https://www.do...
sizzle 4y ago
Here is the original non-expert article with similar title: https://news.yahoo.com/first-human-patient-injected-revolutionary-140900099.html https://news.yahoo.com/first-human-patient-injected-revoluti... It obscured the link to the actual clinical trial. Also front page of Reddit: https://www.reddit.com/r/worldnews/comments/uvplpj/first_human_patient_injected_with_revolutionary/ https://www.reddit.com/r/worldnews/comments/uvplpj/first_hum... AMA with creator of vaccinia oncolytic viruses here: https://www.reddit.com/r/worldnews/comments/uvplpj/comment/i9n7nbg/ https://www.reddit.com/r/worldnews/comments/uvplpj/comment/i...
- dontbenebby 4y ago
  Oh I can't post on Reddit anymore. People purposefully started sitewide banning me whenever I'd get a decent social media following. (Have you used Mastadon? I'm considering checking that out) It was a running joke that I don't look at logs for too long, stemming back to when I did a now deleted blog that listed a way to spoof your location on Facebook and I posted it with zero warning. It was literally just editing Firefo about:config and manually writing out the coordinates, not really even an input sanitization error IMHO. I got the impression it made some people lose face that I had no security clearance, I was just some random hourly worker who threw my boss' name around too much as I attended a lot of stuff listed as open to the public where people who had TS or TS:SCI questions would show up and ask troll-ish questions. (That leaks a LOT of information. Don't do that, if you're reading.) I'll take a look though, thanks for the links, sincerely.

boppo1 4y ago

You shouldn't be able to get away with it in psychology

dontbenebby 4y ago
> You shouldn't be able to get away with it in psychology Then next time you find a study you don't like, contact the IRB[1] that authorized it and contact your representative in Congress[2]. They publish the grant information. Say you'd prefer to receive that money instead, or that it be directed to a more ethical and useful primary investigator. [1] https://en.wikipedia.org/wiki/Institutional_review_board#United_States_mandate_for_IRBs https://en.wikipedia.org/wiki/Institutional_review_board#Uni... [2]https://www.congress.gov/members/find-your-member https://www.congress.gov/members/find-your-member
- boppo1 4y ago
  This is helpful, thanks!
  - dontbenebby 4y ago
    No problem, but when you speak to your elected representative, please also say that they should have local police adopt a policy that all police officers carry business officers with detailed contact information. At the meta level if someone "gives me a card" and it's just... the phone number to whoever gatekeeps access to them and an email some assistant monitors, then don't expect the same level of trust, deference, or respect as someone like me who hands out the email tied to their real name, the phone number for the SIM in their phone, and the Signal number tied to the phone number they've held onto since they were 16. (You might notice some of my more recent posts seemed rushed, or erratic. That is because I was posting like a literal dissident: drafting things, posting, then immiedately changing locations. A lot of the rhetoric around "community standards" of speech is more about things like, well, yeah, someone might stand up a server with Mein Kampf or something on it, and that's ok because sometimes people want to read that for academic reasons. Anyways sorry for the wall of text, but when folks spoke to me informally, when I was debating certain roles or... companies... a lot of them spoke of things like "analysis paralysis"[1][2] I see a lot of people nowadays who seem to take the view that if they prominently display a contact phone number and unique identifier, they can move to more of a model where anti-social behavior is the default, and challenge others to report out to some... entity... to come and deal with the issue. (Versus making a good faith effort to follow the guidlines, and being willing to accept sincere feedback.) Anyways sorry to wall of text you, but it's been really interesting seeing how people react to me versus others on the internet, especially when I take a long pause from posting here on the orange website ;-) [1] https://web.archive.org/web/20150921200100/https://theintercept.com/2015/05/28/nsa-officials-privately-criticize-collect-it-all-surveillance/ https://web.archive.org/web/20150921200100/https://theinterc... [2] https://web.archive.org/web/20150723204817mp_/https://www.documentcloud.org/documents/2088983-too-many-choices.html https://web.archive.org/web/20150723204817mp_/https://www.do...

sizzle 4y ago

Here is the original non-expert article with similar title: https://news.yahoo.com/first-human-patient-injected-revolutionary-140900099.html https://news.yahoo.com/first-human-patient-injected-revoluti... It obscured the link to the actual clinical trial. Also front page of Reddit: https://www.reddit.com/r/worldnews/comments/uvplpj/first_human_patient_injected_with_revolutionary/ https://www.reddit.com/r/worldnews/comments/uvplpj/first_hum... AMA with creator of vaccinia oncolytic viruses here: https://www.reddit.com/r/worldnews/comments/uvplpj/comment/i9n7nbg/ https://www.reddit.com/r/worldnews/comments/uvplpj/comment/i...

dontbenebby 4y ago
Oh I can't post on Reddit anymore. People purposefully started sitewide banning me whenever I'd get a decent social media following. (Have you used Mastadon? I'm considering checking that out) It was a running joke that I don't look at logs for too long, stemming back to when I did a now deleted blog that listed a way to spoof your location on Facebook and I posted it with zero warning. It was literally just editing Firefo about:config and manually writing out the coordinates, not really even an input sanitization error IMHO. I got the impression it made some people lose face that I had no security clearance, I was just some random hourly worker who threw my boss' name around too much as I attended a lot of stuff listed as open to the public where people who had TS or TS:SCI questions would show up and ask troll-ish questions. (That leaks a LOT of information. Don't do that, if you're reading.) I'll take a look though, thanks for the links, sincerely.