Anything going directly into the colon is bypassing a number of the body's protective mechanisms: "Prostaglandin E2 in human semen given via anus during anal i

Anything going directly into the colon is bypassing a number of the body's protective mechanisms: "Prostaglandin E2 in human semen given via anus during anal intercourse may cause an immune dysregulation in the male semen recipients; this immunosuppressive effect of prostaglandin E2 may be one of the underlying factors that stimulate AIDS-associated virus infection or that trigger the latent AIDS-associated virus. This hypothesis is supported by the following experimental results. Anal infusion of prostaglandin E2 or D2 into male rats reduced in vitro responses of T lymphocytes to phytohemagglutinin. However, the T-cell response of female rats was not reduced significantly by the anal infusion of seminal prostaglandins." https://pubmed.ncbi.nlm.nih.gov/3458226/ https://pubmed.ncbi.nlm.nih.gov/3458226/ "This method of alcohol consumption can be dangerous and even deadly because it leads to faster intoxication than drinking since the alcohol is absorbed directly into the bloodstream and bypasses the body's ability to reject the toxin by vomiting." https://en.wikipedia.org/wiki/Alcohol_enema https://en.wikipedia.org/wiki/Alcohol_enema