This is a phase I study. The point here is to establish safety. The study believes this treatment could have a benefit for patients, but they aren’t sure if the

This is a phase I study. The point here is to establish safety. The study believes this treatment could have a benefit for patients, but they aren’t sure if there are unknown risks. This is to establish that there aren’t any unknown risks. The eligible patient population has already advanced on therapy (meaning the current standard of care hasn’t worked). Getting patients to any sort of long-term response is the goal here. If there are any long term risks, that would be considered a good outcome (because the patient is still alive to have long term effects). Any further (heritable genetic) risks are mitigated as the patients specifically are excluded if they are planning on having children in the near future.