4 ms·
It wouldn't happen to be a monkeypox virus, would it?
by im3w1l 4y ago
It wouldn't happen to be a monkeypox virus, would it?
- Brybry 4y agoNo. CF33 appears to be a chimera of nine viruses: six strains of VACV, cowpox, rabbitpox, and raccoonpox created in monkey cells[1]. Seems to be mostly vaccinia (VACV)[2][3]. [1] https://pubmed.ncbi.nlm.nih.gov/29988502/ https://pubmed.ncbi.nlm.nih.gov/29988502/ page 18 [2] https://www.cell.com/molecular-therapy-family/methods/fulltext/S2329-0501(21)00188-1#tbl1 https://www.cell.com/molecular-therapy-family/methods/fullte... [3] https://www.nature.com/articles/s41417-019-0114-x https://www.nature.com/articles/s41417-019-0114-x
- echelon 4y agoNice zombie reference. But for those curious, > CF33, and its genetically modified variants (CF33-hNIS-ΔF14.5L and CF33-hNIS-antiPDL1). The creation of CF33 and its sequenced genome has been previously described (11). Briefly, recombination among 9 different species/strains of orthopoxviruses [Cowpox (Brighton), raccoonpox (Herman), rabbitpox (Utrecht), vaccinia virus (Western Reserve), International Health Department, Elstree, and VACV strains Ankara (AS)] resulted in a chimeric orthopoxvirus, CF33, which did not previously exist in nature. This virus has been found to be highly specific for infection, replication within, and killing of breast cancer and pancreatic cancer (11, 12). From https://www.sciencedirect.com/science/article/am/pii/S1072751520301150 https://www.sciencedirect.com/science/article/am/pii/S107275...