Ok, this is a huge reach, but: with big endian, you can determine the sign of the int at a pointer address without knowing the width of what's pointed at, with

Ok, this is a huge reach, but: with big endian, you can determine the sign of the int at a pointer address without knowing the width of what's pointed at, with little endian, the parity. It's hard for me to call either of those advantages in anything but the most technical sense, but it's there.