you can leave your web stuff at the door. unless you have a really good reason to use client/server architecture, or make everything async, just write your mono

you can leave your web stuff at the door. unless you have a really good reason to use client/server architecture, or make everything async, just write your monolithic desktop app using a framework like QT which will interface with a database out of the box. or you can interface with sqlite directly. if you only need windows or mac support you can use platform specific languages and UI frameworks.