I'd second this. It takes a bit of work, but puts you nicely into a MVC framework and makes it easy enough to bring in developers/designers. Developing in Djang

I'd second this. It takes a bit of work, but puts you nicely into a MVC framework and makes it easy enough to bring in developers/designers. Developing in Django would be for a side-project, but if you write your app in a new framework, you'll find that you have to go back and fix most of what you initially write. It's not a bad thing necessarily, as long as you're not concerned with speed-to-market and (initial) code-quality. As some others have said, do a small side-project (I'm sure you have dozens of ideas!) to get into the swing of python/django. Either decide what framework to use and start from there, or immediately begin work on your webapp while picking up the Django skills. Good luck either way!