3 ms·

What's the best way to contact you? I've been fighting brain cancer for 7 years and work closely with a group of neuro-oncologists, researchers, non-profits, an

by jabrams2003 4y ago

What's the best way to contact you? I've been fighting brain cancer for 7 years and work closely with a group of neuro-oncologists, researchers, non-profits, and investors in the space. I'd love to chat.

coolwulf 4y ago
Feel free to send me emails: coolwulf@gmail.com
- panabee 4y ago
  this is incredible. thanks. 1. do you have a patreon or something where people can support you? 2. do you know how to obtain the nucleotide sequences of c-MYC? 3. have you seen machine learning applications that can predict protein function? specifically, the goal is to predict if protein X could participate in cleaving of DNA similar to CRISPR Cas9? false positives are okay, provided the negatives are accurate (i.e., guarantees protein cannot cleave DNA like Cas9).
  - elmolino89 4y ago
    >do you know how to obtain the nucleotide sequences of c-MYC? Check: https://www.ensembl.org/Homo_sapiens/Transcript/Summary?db=core;g=ENSG00000136997;r=8:127735434-127742951;t=ENST00000621592 https://www.ensembl.org/Homo_sapiens/Transcript/Summary?db=c... This is the main transcript, the remaining 9 are in the table
    - panabee 4y ago
      thanks so much! would it be possible to contact you for other questions? or could you recommend a reddit sub for questions like this? researchgate doesn't seem responsive. for instance, how to obtain the nucleotide sequences for TP53, or for the NHN/RuvC domains of CRISPR Cas9? thanks again for your help.
      - elmolino89 4y ago
        Re p53: same site (ENSEMBL): https://www.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000141510;r=17:7661779-7687538 https://www.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=... also you can check human genes at GeneCards: https://www.genecards.org/ https://www.genecards.org/ re other questions: The crucial thing is: what are your goals? Bioinformatics and cancer biology in particular are rather vast fields. Questions and answers make sense if you can place what you just got in some framework. And getting there is non-trivial, see i.e. +800pp book: https://www.amazon.com/Lewins-GENES-XII-Jocelyn-Krebs/dp/1284104494 https://www.amazon.com/Lewins-GENES-XII-Jocelyn-Krebs/dp/128...
        panabee 4y ago
        thanks so much. genecards looks interesting. is it possible to find nucleotide sequences from amplified c-MYC from cancerous tissue, either burkitt's lymphoma or TNBC? ensembl is valuable, but it would be more efficient to hire someone to decode the different options. what type of researchers understand the different sequence options on an ensembl page: cancer biologist, geneticist, bioinformatics scientist? thanks again for your help! the goal is conducting some first-principles analysis of cancer, nothing fancy and very likely a waste of time.
throwaway122385 4y ago
if at this point in the game no one has advised you to eat organic, consider it

coolwulf 4y ago

Feel free to send me emails: coolwulf@gmail.com

panabee 4y ago
this is incredible. thanks. 1. do you have a patreon or something where people can support you? 2. do you know how to obtain the nucleotide sequences of c-MYC? 3. have you seen machine learning applications that can predict protein function? specifically, the goal is to predict if protein X could participate in cleaving of DNA similar to CRISPR Cas9? false positives are okay, provided the negatives are accurate (i.e., guarantees protein cannot cleave DNA like Cas9).
- elmolino89 4y ago
  >do you know how to obtain the nucleotide sequences of c-MYC? Check: https://www.ensembl.org/Homo_sapiens/Transcript/Summary?db=core;g=ENSG00000136997;r=8:127735434-127742951;t=ENST00000621592 https://www.ensembl.org/Homo_sapiens/Transcript/Summary?db=c... This is the main transcript, the remaining 9 are in the table
  - panabee 4y ago
    thanks so much! would it be possible to contact you for other questions? or could you recommend a reddit sub for questions like this? researchgate doesn't seem responsive. for instance, how to obtain the nucleotide sequences for TP53, or for the NHN/RuvC domains of CRISPR Cas9? thanks again for your help.
    - elmolino89 4y ago
      Re p53: same site (ENSEMBL): https://www.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000141510;r=17:7661779-7687538 https://www.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=... also you can check human genes at GeneCards: https://www.genecards.org/ https://www.genecards.org/ re other questions: The crucial thing is: what are your goals? Bioinformatics and cancer biology in particular are rather vast fields. Questions and answers make sense if you can place what you just got in some framework. And getting there is non-trivial, see i.e. +800pp book: https://www.amazon.com/Lewins-GENES-XII-Jocelyn-Krebs/dp/1284104494 https://www.amazon.com/Lewins-GENES-XII-Jocelyn-Krebs/dp/128...
      - panabee 4y ago
        thanks so much. genecards looks interesting. is it possible to find nucleotide sequences from amplified c-MYC from cancerous tissue, either burkitt's lymphoma or TNBC? ensembl is valuable, but it would be more efficient to hire someone to decode the different options. what type of researchers understand the different sequence options on an ensembl page: cancer biologist, geneticist, bioinformatics scientist? thanks again for your help! the goal is conducting some first-principles analysis of cancer, nothing fancy and very likely a waste of time.

throwaway122385 4y ago

if at this point in the game no one has advised you to eat organic, consider it