I disagree just on the grounds that if they're confident it affects serotonin 1A receptors then there's definitely a decent chance it really does _something_. A

I disagree just on the grounds that if they're confident it affects serotonin 1A receptors then there's definitely a decent chance it really does _something_. As mentioned Buspar/Buspirone is prescribed for anxiety and affects that exact receptor the most. Similarly I've seen NAC recommended a lot - by a doctor with a phd in neuropsychology. There's a lot of positive reports about it for several mental illnesses - and there's also reason to beleive it affects glutamate (and in turn GABA). I think the truth is that many chemicals (or plants) are overlooked. As long as there's a solid idea as to what the mechanism of action is, then I think it has a very real chance of being beneficial to someone. This wouldn't be the first psychoactive plant/fungus - Cacao, mushrooms, kava, marijuana, acaia (dmt) and opium are all relatively potent (noticable within an hour).