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Recently a Chinese media interviewed me and I talked about a few side projects I have done in the past. I talked about the Neuralrad Mammo Screening project and
by coolwulf 4y ago
Recently a Chinese media interviewed me and I talked about a few side projects I have done in the past. I talked about the Neuralrad Mammo Screening project and Neuralrad multiple brain mets SRS platform. More awareness on radiation therapy to the general public will greatly help the community and we believe Stereotactic Radiosurgery (SRS) will eventually replace majority of the whole brain radiation therapy (WBRT) in the next five years.
Here is the link to the original article:
https://www.toutiao.com/article/7094940100450107935/ https://www.toutiao.com/article/7094940100450107935/
- mamborambo 4y agoSuper impressed. Amateurs can and do play their parts in science --- there are numerous discoveries made in astronomy, mathematics, and definitely in computer applied sciences that sprang from the minds of amateurs.
- sylware 4y agojavascript only link. Any compatible link with noscript/basic (x)html browsers?
- jjeaff 4y agoAnd I would like the content sent to me in Morse code via telegraph.
- fL0per 4y agohttps://telegra.ph/This-amateur-programmer-once-used-50-1080Ti-cards-to-fight-cancer-05-21 https://telegra.ph/This-amateur-programmer-once-used-50-1080... There, it may content errors, since it's a machine translated copy what had to be telegraphed by the operator. Thank him, he's a brilliant guy.
- ska 4y agoWBRT is pretty brutal. Am I right in thinking you are focusing on multiple site treatment/palliative treatment of metastatic presentations? High site count also or sticking to say < 5?
- coolwulf 4y agoExactly, I'm working on a workflow platform for multiple brain metastasis stereotactic radiosurgery. This will greatly benefit patients with more than 5 BMs.
- ska 4y agoCool stuff! I've done some work in adjacent areas - there are huge challenges (not only technical) but great to feel you are making an impact.
- samstave 4y agoELI5, please.
- ska 4y agoMetastatic disease is when a cancer spreads to multiple locations. This can make it difficult/impossible/impractical to treat effectively, especially surgically. Whole brain radiotherapy works by killing everything a little bit in the hopes that the tumors die first (e.g. like chemo). There are good reasonswhy this tends to mostly-sort-of be true, but getting the balance right is hard and too much dose will definitely cause other problems. SRS is a way of targeting radiation directly to locations to kill cells, with less effective dose (hence damage) to other parts of the brain. It's all pretty harsh stuff, and you can die from the necrotic tissue caused by it, also. Often with this kind of disease you know you aren't going to cure someone, but you can get rid of symptoms and make people more comfortable (palliative care).
- abfan1127 4y agoGoogle Translate link - https://www-toutiao-com.translate.goog/article/7094940100450107935/?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=en&_x_tr_pto=wapp&wid=1653064063070 https://www-toutiao-com.translate.goog/article/7094940100450...
- gregsadetsky 4y agoThanks -- and here's the site as well -- http://mammo.neuralrad.com:5300/upload http://mammo.neuralrad.com:5300/upload
- pen2l 4y agoOh, it's you! What a beacon of light and inspiration you are. Thanks for your work. That said, I welcome you to publish your work so it can become even better after a formalized peer-review process.
- coolwulf 4y agoFor the multiple brain mets SRS project, we will be presenting at this year's AAPM annual meeting.
- jacquesm 4y agoSuper effort. I understand your reluctance to accept funding but if you ever change your mind on that be sure to publish it here on HN. If giving you more tools means more progress in this domain without the usual red tape then I'm all for giving you as much of a push as possible.
- justinclift 4y agoAs a general thought, it's super easy to start a Patreon account to accept donations. Seems pretty effective. :)
- Simon_O_Rourke 4y agoThank you for all you've done for people, it's amazing and inspiring!
- hehepran 4y agoSir, you are super cool.
- Billsen 4y agoNice job!
- llaolleh 4y agoYour story was inspirational. It's really cool to run this project to help others without expecting any payment.
- daniel-cussen 4y agoUnless it's more expensive than existing treatments the medical industry will close the circles around you excluding you. That's why not one startup has hacked healthcare in America, not one. No breakaway successes making pharma cheaper. Like those incubators in Bangladesh, for premature babies not startups that is, those did OK. Some pill startups yes, but again that's an expensivification of medicine. If you can make medicine more expensive, they welcome you in! Jim Clark tried this, he was on a roll after Silicon Graphics and Netscape. Huge roll about as strong as Elon Musk as a serial entrepreneur. Then he targeted healthcare and couldn't do shit, just couldn't get anything to happen. He literally talked about getting "rid of all the assholes" by which he meant insurance and doctors and hospitals and middlemen and pharma and all the other "assholes" of that nature in his own words, but leave "only one asshole in the middle--us [paraphrased]." It's in a book. That book also talks about guys going on airplanes and chasing goats off cliffs, saying "Some people do this." Well the real structure of medicine isn't designed around the human body, it's designed around cornering the market. Market dominance. So of course it has this immune system against cost reduction and efficiencies--efficiencies especially--and you do know it lobbies, don't you? And can bribe the FDA like the Sacklers did? Or lobby the FDA, and then bribe underneath so when people see favoritism they think it's the over-the-counter placebo causing a placebo effect without suspecting an additional more potent under-the-table dosage of money. In case the administration has built up a tolerance to the over-the-counter stuff.
- quickthrower2 4y agoWhat about the NHS in the UK? They should be more aligned to wanting cheaper cancer diagnosis and also anything to help people. If America has dysfunctional healthcare there is still the rest of the world. Which might be good for Americans eventually as the tech will come across one way or another.
- anamax 4y ago> If America has dysfunctional healthcare there is still the rest of the world. Which might be good for Americans eventually as the tech will come across one way or another. Which raises the question - why does the vast majority of healthcare tech development come from the US? (I included "development" to get around the out-sourcing of testing to China.)
- rob_c 4y agoFantastic work dude. On behalf of anyone who might one day benefit thanks and congrats.
- jabrams2003 4y agoWhat's the best way to contact you? I've been fighting brain cancer for 7 years and work closely with a group of neuro-oncologists, researchers, non-profits, and investors in the space. I'd love to chat.
- coolwulf 4y agoFeel free to send me emails: coolwulf@gmail.com
- panabee 4y agothis is incredible. thanks. 1. do you have a patreon or something where people can support you? 2. do you know how to obtain the nucleotide sequences of c-MYC? 3. have you seen machine learning applications that can predict protein function? specifically, the goal is to predict if protein X could participate in cleaving of DNA similar to CRISPR Cas9? false positives are okay, provided the negatives are accurate (i.e., guarantees protein cannot cleave DNA like Cas9).
- elmolino89 4y ago>do you know how to obtain the nucleotide sequences of c-MYC? Check: https://www.ensembl.org/Homo_sapiens/Transcript/Summary?db=core;g=ENSG00000136997;r=8:127735434-127742951;t=ENST00000621592 https://www.ensembl.org/Homo_sapiens/Transcript/Summary?db=c... This is the main transcript, the remaining 9 are in the table
- panabee 4y agothanks so much! would it be possible to contact you for other questions? or could you recommend a reddit sub for questions like this? researchgate doesn't seem responsive. for instance, how to obtain the nucleotide sequences for TP53, or for the NHN/RuvC domains of CRISPR Cas9? thanks again for your help.
- elmolino89 4y ago
- rg111 4y agoHi. Some great projects. What's more commendable is your dedication towards your projects and seeing them through to end- to the point that they are actually useful. This is what I truly admire. I have a question for you. What is the tech stack that you use? And if it is not too much: What resources did you use to learn Deep Learning?
- koprulusector 4y ago> Recently a Chinese media interviewed me and I talked about a few side projects I have done in the past. I apologize if this has been asked and answered before, but do you speak Mandarin, or was the interview in English? Asking out of curiosity if it’s the former, and if so, how difficult was it to learn whilst also working on this and other things? And are there any resources or tips you might share that you found helpful?
- qzw 4y agoAccording to the article, Coolwulf went to Nanjing University for undergrad, so pretty safe to assume he would do an interview with Chinese media in Mandarin. And since he likely grew up in China, it was probably very easy for him to learn Mandarin indeed!
- onetimeusename 4y agoWhere did you learn to program on distributed Nvidia GPUs? The article implied you were self taught and learning to do this is quite challenging for various reasons. Not least, Nvidia's documentation is not the best resource to learn from. This seems like quite a lot of work to understand ML and write custom CUDA code to get this to work. Do you have any insight about how you taught yourself these things and what tools you use?
- MaximumYComb 4y agoI'm not your OP but I learnt all these things at univeristy during my BCompSci. Understanding ML algorithms came down to a lot of math / statistics units. I learnt about parallel computing during a dedicated unit called "Distributed and Parallel Computing"
- jacquesm 4y agoNot the OP but I taught myself in a couple of weeks picking apart some of the sample CUDA code and reading some of the (excellent) pdfs on the architecture of the Nvidia range. At the time the GTX285 was hot stuff, the same code runs unchanged on a 1080ti and I would expect it to continue to work on even more modern incarnations. CUDA is pretty good as a platform to build on if you understand the basic idea behind the engine, and some low level experience will come in very handy. And ML on CUDA vs ML in C or some other language is typically a matter of shuttling the data and the results back and forth between main memory and the card as well as implementing the most time consuming portions of the algorithm you are using in a custom kernel, you can usually get 50% or so of the theoretical maximum speed with relatively little effort. Getting to full speed is going to be a lot harder, but then you could of course also add another card (or another three) get get an instant boost. Usually you would - nowadays at least - use someone else's optimized kernel + ML library but if you wanted to roll your own that's doable.
- Thorrez 4y agoDid coolwulf write his own CUDA code, or use machine learning libraries that already come with CUDA implementations, like TensorFlow or PySpark?
- FpUser 4y agoI am not a religious man at all but God Bless you. You are an amazing human being and a source of inspiration.
- dclowd9901 4y agoAs a “professional” programmer, I’m humbled by your accomplishments. I really must find ways to contribute more to the world. It seems there’s a lot of opportunities in AI to do it.
- iaw 4y agoYou're clearly well accomplished in multiple areas. How do approach learning something new?
- sizzle 4y agoImagine for a moment if FB and Google took all their developers and resources and applied it to solving cancer, how long do you think it would take to make a dent in the problem space? Or is there a hard limit stopping us from progressive like Moores law for scientific understanding.
- SV_BubbleTime 4y agoYea… but instead, ads are like 3% more effective each year. So, you know, silver linings.
- deleted 4y ago[deleted]
- NLPlatypus 4y agoGoogle does have a company Calico (California Life Corporation) (I’m hoping to work there after my PhD)
- SV_BubbleTime 4y agoSure if you are willing to ignore all evidence and instead go with a hopeful expectation of “doing good”.
- throwaway0220 4y ago> Imagine for a moment if FB and Google took all their developers and resources... It's a nice thought exercise, but of course not realistic. FAANGs wouldn't be able to attract or retain the talent if they were purely in scientific medical research (where do you think those fancy offices and fat paychecks comes from?). Having said that, it doesn't have to be either/or. I strongly believe that companies can be successful in balancing between thriving commercial businesses and using its profits to advance research that can benefit the society at large. Case in point: Google's DeepMind has for years published groundbreaking work in various areas including breast cancer research [1], protein folding [2], energy savings and climate change [3], and more. Also Calico [4], or its investments in health startups via GV, and of course all the well known services to users. What I'd like to see is more companies following a path where a portion of its profits is used to fund research in areas that can cause societal change for the better (which, in its turn, may eventually became new sources of revenue down the road - e.g. protein folding, self-driving cars). (disclaimer: Googler here, but no relationship with any of the projects mentioned) [1] https://www.deepmind.com/publications/international-evaluation-of-an-ai-system-for-breast-cancer-screening https://www.deepmind.com/publications/international-evaluati... [2] https://www.technologyreview.com/2021/07/22/1029973/deepmind-alphafold-protein-folding-biology-disease-drugs-proteome/ https://www.technologyreview.com/2021/07/22/1029973/deepmind... [3] https://www.deepmind.com/blog/real-world-challenges-for-agi https://www.deepmind.com/blog/real-world-challenges-for-agi [4] https://www.calicolabs.com/ https://www.calicolabs.com/
- sdo72 4y agoThank you for doing this, you deserve a superhero badge! It's very inspirational.
- nkzd 4y agoYou are an inspiration. Thank you for restoring my faith in this field.
- Abishek_Muthian 4y agoSir, We've all been hearing that AI will revolutionize medical diagnostics for a long time, seen startups come & go in this space but seeing your work impact lives on the ground has convinced me that the secret missing ingredient was a self-less human who can build an accessible(non-commercial) solution for the masses. A decade ago I did a voluntary work on a simple app for oral cancer detection(questionnaire, data-entry) with an oncologist, Who used it to for survey in the tribal regions of India and he used to say how lack of early detection is the number one reason for so many deaths(many die without knowing that they had cancer). He's now settled in Germany, But I would still pass this story to him & perhaps his colleagues in India could make use of it. Thank you.
- rawgabbit 4y agoYou are a hero. God bless you and thank you for efforts to help others.
- adultSwim 4y agoGreat work. I'm inspired seeing others use their skills to work on something important. So many of the smartest, most well educated engineers of my generation have put their talents to use doing things that are of little value to society. Thank you for demonstrating to us what else is possible.