> The variation lies in different utilization rate, the burn rate, and all other variables, but within the limit of PHYSICS. CICO is useful as an upper bound o

> The variation lies in different utilization rate, the burn rate, and all other variables, but within the limit of PHYSICS. CICO is useful as an upper bound on calorie utilization, but unfortunately not relevant to the problem of obesity, which deals with the exact opposite end of the problem space. CICO might be important if the problem was that people in first world nations were starving due to an insufficient supply of calories. But the obesity epidemic indicates that this is not the case. So CICO is relevant to the problem in the same way that a theoretical understanding of the gasoline-air reaction is relevant to understanding why my car's gas mileage has dropped recently.