5 ms·

Even non-reactive particles like asbestos can cause a persistent inflammatory response eventually leading to cancer, chronic fatigue, malaise, etc. The ones tha

Even non-reactive particles like asbestos can cause a persistent inflammatory response eventually leading to cancer, chronic fatigue, malaise, etc. The ones that get the most attention these days are PM-2.5: tiny particles or droplets in the air that are two and one half microns or less in width, penetrate alveoli, and go straight into your blood stream. More info: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740125/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740125/ In about a decade or two brake dust pollution will be more recognized as a severe public health problem. It's not on the hype cycle yet. https://pubmed.ncbi.nlm.nih.gov/32593898/ https://pubmed.ncbi.nlm.nih.gov/32593898/

xxpor 4y ago
Not just brake dust (which is probably solvable), but also rubber from tires.
scotty79 4y ago
But pure carbon is somewhat reactive, so maybe it could be cleaned by the body. Is it not?
- orangepurple 4y ago
  Not sure, but there is definite collateral damage because it is biologically active. From Fig 2. of https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789336/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789336/ Mechanism of DNA methylation and histone modification alterations induced by nanomaterials and nanoparticles: Exposure to NMs and NPs alters the functioning of chromatin-modifying proteins, e.g., DNA methylation and demethylation machinery, and histone-modifying enzymes, causing changes in the pattern of DNA methylation and histone modifications. One of the most common effects of NMs and NPs is the induction of cellular stress, e.g., oxidative and endoplasmic reticulum stress, and metabolic disturbances, e.g., one-carbon metabolism and the citric acid cycle. These events are causing DNA damage and repair response and metabolic alterations affecting the functioning of chromatin-modifying enzymes. Any or all of these events may result in hypomethylation of DNA and altered histone modification patterns. Additionally, exposure to NMs and NPs causes activation of the inflammatory response that, in turn, may cause DNA hypermethylation and histone modification changes

xxpor 4y ago

Not just brake dust (which is probably solvable), but also rubber from tires.

scotty79 4y ago

But pure carbon is somewhat reactive, so maybe it could be cleaned by the body. Is it not?

orangepurple 4y ago
Not sure, but there is definite collateral damage because it is biologically active. From Fig 2. of https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789336/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789336/ Mechanism of DNA methylation and histone modification alterations induced by nanomaterials and nanoparticles: Exposure to NMs and NPs alters the functioning of chromatin-modifying proteins, e.g., DNA methylation and demethylation machinery, and histone-modifying enzymes, causing changes in the pattern of DNA methylation and histone modifications. One of the most common effects of NMs and NPs is the induction of cellular stress, e.g., oxidative and endoplasmic reticulum stress, and metabolic disturbances, e.g., one-carbon metabolism and the citric acid cycle. These events are causing DNA damage and repair response and metabolic alterations affecting the functioning of chromatin-modifying enzymes. Any or all of these events may result in hypomethylation of DNA and altered histone modification patterns. Additionally, exposure to NMs and NPs causes activation of the inflammatory response that, in turn, may cause DNA hypermethylation and histone modification changes