3 ms·
We don't have to guess.. it's literally in the article. This is a Phase 1 trial purely to test safety and immunogenicity. More details: > The IAVI-sponsored t
by mikeyouse 4y ago
We don't have to guess.. it's literally in the article. This is a Phase 1 trial purely to test safety and immunogenicity.
More details:
> The IAVI-sponsored trial, IAVI G003, builds on progress in HIV vaccine research. Recent findings from the Phase I clinical trial IAVI G001 showed that vaccination with the HIV immunogen eOD-GT8 60mer as a recombinant protein safely induced the targeted immune responses in 97% of recipients (healthy U.S. adults). The immune response — targeting and expanding a specific class of B cells — is needed to start the process of developing broadly neutralizing antibodies (bnAbs). The induction of bnAbs is widely considered to be a goal of an efficacious HIV vaccine, and this B-cell activation is the first step in that process. IAVI G003 is designed to test the hypothesis that vaccination with eOD-GT8 60mer, developed by scientific teams at IAVI and Scripps Research, delivered via Moderna’s mRNA platform, can induce similar immune responses in African populations as was seen for IAVI G001.