3 ms·

In pharmacology we have many enzyme inhibitors, that reduce their activity. Conversely, are there ways to either increase the rate of productivity of an enzyme,

• etiam 4y ago
  Many of them have probably tried hard for a long time at increasing efficacy. Other than addressing possible shortages of substrates and co-factors that seems like more trouble than it's worth most of the time? More of the enzyme... Try homeopathy but don't dilute so much? (Production of inducible enzymes is upregulated based on environmental cues, often some variant of failing to work fast enough at catalyzing whatever they work on, ethanol being one popular example). The fancier way would be trying to find a suitable set of transcription factors to stimulate expression and get those into the right cells and compartments I guess.
  • SemanticStrengh 4y ago
    I'm pretty sure there must be molecules or signaling pathways that upregulate specific enzymes but yeah as you say, epigenetically via specifically made peptides or genetically via mRNA injections, one could increase the quantity of a specific ensyme, the easyness being a product of how well delineated and specific are the genes/allele responsible for its encoding. The medicinal applications are endless, e.g. increasing FAAH ensymes for next-gen sleep enhancers, or increasing specific ratios of phosphodiesterases for next-gen mood stabilisers/antypsychotics/anticonvulsants/antiepilleptics. It seems like a very underfunded generic target.